INT100051

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 14.21
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC5AC) cell adhesion (MUC5AC)
Anatomy Link Frequency
gastric epithelium 2
spinal 1
pancreas 1
cranial nerve 1
MUC5AC (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 100.00 Very High Very High Very High
epidural 1 100.00 Very High Very High Very High
GABAergic 46 95.76 Very High Very High Very High
Inflammation 149 82.44 Quite High
dexamethasone 4 79.52 Quite High
corticosteroid 2 78.64 Quite High
headache 12 75.04 Quite High
metalloproteinase 20 73.52 Quite High
gABA 59 72.52 Quite High
Central nervous system 19 69.20 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 501 100.00 Very High Very High Very High
Mycobacterial Infection 226 100.00 Very High Very High Very High
Adhesions 65 100.00 Very High Very High Very High
Pulmonary Disease 5 100.00 Very High Very High Very High
Apnoea 2 100.00 Very High Very High Very High
Nicotine Addiction 68 99.92 Very High Very High Very High
Meningitis 76 99.80 Very High Very High Very High
Pancreatic Cancer 29 99.76 Very High Very High Very High
Cranial Neuropathy 1 97.68 Very High Very High Very High
Bacterial Meningitis 13 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EXPERIMENTAL DESIGN: Total RNA from 16 pancreatic tumors, 10 chronic pancreatitis tissues, 7 normal pancreas tissues, and 15 pancreatic tumor cell lines were analyzed by reverse transcription-PCR with primers specific for MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7 genes and by RNA slot blot analyses.
MUC5AC Spec (analyses) Binding (specific) of in pancreas
1) Confidence 0.32 Published 2001 Journal Clin. Cancer Res. Section Body Doc Link 11751498 Disease Relevance 0.35 Pain Relevance 0
The ingestion dose coefficients were calculated as 2.8 x 10(-8), 2.1 x 10(-8), 2.5 x 10(-8) and 3.8 x 10(-8) Sv Bq(-1) for ICRP, SENES, TBM and GSF model parameters, respectively.
TBM Binding (2.8) of
2) Confidence 0.32 Published 2008 Journal Radiat Environ Biophys Section Abstract Doc Link 18204850 Disease Relevance 0.32 Pain Relevance 0
Diagnosis of TBM and PTPM was based on the criteria described below.


TBM Binding (Diagnosis) of associated with mycobacterial infection and meningitis
3) Confidence 0.28 Published 2004 Journal BMC Neurol Section Body Doc Link PMC529262 Disease Relevance 1.78 Pain Relevance 0.11
Marked up-regulation of GAD67 by cigarette smoking is associated with MUC5AC overexpression.
MUC5AC Binding (associated) of associated with nicotine addiction
4) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.60 Pain Relevance 0.25
The present work is the first demonstration of an association of MUC5AC with pancreatic cancer cell invasion.
MUC5AC Binding (association) of associated with pancreatic cancer
5) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2893453 Disease Relevance 1.01 Pain Relevance 0.04
A reliable and rapid diagnostic test, which can be performed in any standard pathology laboratory, can be of help in diagnosis of TBM.
TBM Binding (diagnosis) of associated with mycobacterial infection
6) Confidence 0.24 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1578580 Disease Relevance 0.75 Pain Relevance 0.06
The de-adhesion force appears predominantly as multiples of an elementary force, which is determined to 25+/-1.5 pN and identified as the unbinding force of an individual BabA-Leb binding.
Leb Binding (binding) of associated with adhesions
7) Confidence 0.23 Published 2005 Journal J Biomed Opt Section Abstract Doc Link 16178657 Disease Relevance 0.76 Pain Relevance 0.07
Their binding properties were analyzed by RIA [31]: J170, J254, J166, and J258 bound both sLex and Leb, J282 bound Leb, and J178 bound sLex.


Leb Binding (bound) of
8) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.40 Pain Relevance 0
Their binding properties were analyzed by RIA [31]: J170, J254, J166, and J258 bound both sLex and Leb, J282 bound Leb, and J178 bound sLex.


Leb Binding (bound) of
9) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.40 Pain Relevance 0
Their binding properties were analyzed by RIA [31]: J170, J254, J166, and J258 bound both sLex and Leb, J282 bound Leb, and J178 bound sLex.


Leb Binding (bound) of
10) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.40 Pain Relevance 0
The J99 wild type strain possesses both adhesins, and bound to the adhesion ligands Leb and sLex (Figure 2A).
Leb Binding (bound) of associated with sprains and strains and adhesions
11) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.29 Pain Relevance 0
H. pylori strains differ in their expression of the BabA and SabA adhesins and consequently in their ability to bind to the Leb, sLea and sLex carbohydrate structures expressed on gastric mucins [11],[13].
Leb Binding (bind) of associated with sprains and strains
12) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.28 Pain Relevance 0
Interestingly, binding to nonsialylated glycans such as Leb was not affected by the improved BSA preparation, which might be due to lack of the human/primate-specific antigen, Leb, in bovine serum constituents.
Leb Binding (binding) of
13) Confidence 0.12 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.33 Pain Relevance 0
As shown in a previous study, a H. pylori babA deletion mutant that cannot bind ABO/Leb blood group antigens nevertheless binds to gastric epithelium [15].
Leb Binding (binds) of in gastric epithelium
14) Confidence 0.09 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.38 Pain Relevance 0.06
As shown in a previous study, a H. pylori babA deletion mutant that cannot bind ABO/Leb blood group antigens nevertheless binds to gastric epithelium [15].
Leb Neg (cannot) Binding (bind) of in gastric epithelium
15) Confidence 0.09 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.32 Pain Relevance 0.03
Our high LEB ratio, when considered along with the bad outcomes, may reflect the late and advanced cases.
LEB Binding (ratio) of
16) Confidence 0.08 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1310632 Disease Relevance 1.19 Pain Relevance 0.03
The 17875/Leb strain is a spontaneous mutant that binds Leb but does not bind to sialylated antigens [15].
Leb Neg (not) Binding (bind) of associated with sprains and strains
17) Confidence 0.08 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.69 Pain Relevance 0.03
The 17875/Leb strain is a spontaneous mutant that binds Leb but does not bind to sialylated antigens [15].
Leb Neg (not) Binding (bind) of associated with sprains and strains
18) Confidence 0.08 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.63 Pain Relevance 0.03
The 17875/Leb strain is a spontaneous mutant that binds Leb but does not bind to sialylated antigens [15].
Leb Neg (not) Binding (binds) of associated with sprains and strains
19) Confidence 0.08 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.69 Pain Relevance 0.03
The 17875/Leb strain is a spontaneous mutant that binds Leb but does not bind to sialylated antigens [15].
Leb Binding (binds) of associated with sprains and strains
20) Confidence 0.08 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.63 Pain Relevance 0.03

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