INT100055

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.04
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC4) cell adhesion (MUC4) proteinaceous extracellular matrix (MUC4)
plasma membrane (MUC4) biological_process (MUC4)
Anatomy Link Frequency
blood 1
pancreas 1
cornea 1
MUC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 47 90.68 High High
imagery 12 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
topical agent 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
diclofenac 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 53 98.64 Very High Very High Very High
Pancreatic Cancer 100 98.60 Very High Very High Very High
Pancreatitis 65 94.00 High High
Cancer 95 92.28 High High
Hyperplasia 6 91.56 High High
Bacterial Respiratory Disease 1 83.64 Quite High
Malignant Neoplastic Disease 18 76.96 Quite High
Glaucoma 26 50.00 Quite Low
Adhesions 9 47.36 Quite Low
Disease 6 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we demonstrated the aberrant MUC4 mRNA expression in 75% (12/16) of the pancreatic adenocarcinoma and 73% (11/15) established pancreatic cancer cell lines [19].
Transcription (expression) of MUC4 associated with adenocarcinoma and pancreatic cancer
1) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.51 Pain Relevance 0.39
Our recently published RT-PCR and Northern blot data support these data and demonstrate the absence of MUC2, MUC3A, MUC4, and MUC7 mRNA in normal pancreatic tissue [19].
Neg (absence) Transcription (absence) of MUC4
2) Confidence 0.69 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.18 Pain Relevance 0
Although MUC4 is present in the cornea, the expression of MUC4 mRNA has been demonstrated in limbal and peripheral cornea, with decreasing levels toward the central cornea [6,7].
Transcription (expression) of MUC4 in cornea
3) Confidence 0.68 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.08 Pain Relevance 0
Indeed, a substantial number of tumor tissue samples (12 of 16) and tumor cell lines (11 of 15) expressed MUC4 mRNA, whereas samples from chronic pancreatitis (0 of 10) and the normal pancreas (0 of 7) tissues failed to exhibit any detectable level of this mucin.
Transcription (expressed) of MUC4 in pancreas
4) Confidence 0.53 Published 2001 Journal Clin. Cancer Res. Section Body Doc Link 11751498 Disease Relevance 0.29 Pain Relevance 0
This pilot study demonstrate the presence of MUC4 mRNA in peripheral blood mononuclear cells of pancreatic cancer patients whereas it was undetectable in PBMCs of healthy volunteers or patients with pancreatitis or patients affected by other cancer types [32].
Transcription (presence) of MUC4 in blood associated with cancer, pancreatitis and pancreatic cancer
5) Confidence 0.51 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.98 Pain Relevance 0.19

General Comments

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