INT100059

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 31.58
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC4) cell adhesion (MUC4) proteinaceous extracellular matrix (MUC4)
plasma membrane (MUC4) biological_process (MUC4)
Anatomy Link Frequency
pancreas 5
surface epithelium 2
pancreatic ducts 2
covering 1
MUC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 222 100.00 Very High Very High Very High
Inflammatory mediators 2 97.76 Very High Very High Very High
metalloproteinase 24 96.68 Very High Very High Very High
imagery 55 96.32 Very High Very High Very High
Inflammation 17 68.56 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 392 100.00 Very High Very High Very High
Pancreatitis 300 100.00 Very High Very High Very High
Pancreatic Cancer 696 99.86 Very High Very High Very High
Cancer 1082 99.76 Very High Very High Very High
Hypersensitivity 7 99.62 Very High Very High Very High
Carcinoma 38 99.44 Very High Very High Very High
Hyperplasia 58 99.24 Very High Very High Very High
Syndrome 150 99.12 Very High Very High Very High
Adhesions 86 98.12 Very High Very High Very High
Bacterial Respiratory Disease 3 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no expression of MUC4 in normal pancreas (0/7) or in chronic pancreatitis tissues (0/10) [19].
Neg (no) Gene_expression (expression) of MUC4 in pancreas associated with chronic pancreatitis
1) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.36 Pain Relevance 0.40
Beside the expression of the full length precursor of MUC4 (sv0-MUC4) with the soluble glycoprotein subunit MUC4?
Gene_expression (expression) of MUC4
2) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.11 Pain Relevance 0.23
The de novo expression of MUC4 in pancreatic adenocarcinoma and cell lines has been reported, a mucin that is usually undetectable in normal pancreas [19,20,23,24].
Gene_expression (expression) of MUC4 in pancreas associated with adenocarcinoma
3) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.43 Pain Relevance 0.38
But it has to be mentioned that despite the high frequency of MUC4 occurrence in pancreatic cancer a fraction is MUC4 negative.
Neg (negative) Gene_expression (negative) of MUC4 associated with pancreatic cancer
4) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.26 Pain Relevance 0.31
In addition, no MUC2, MUC4, or MUC7 expression was detected in normal pancreas.


Gene_expression (expression) of MUC4 in pancreas
5) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.81 Pain Relevance 0
Beside the expression of the full length precursor of MUC4 (sv0-MUC4) with the soluble glycoprotein subunit MUC4?
Gene_expression (expression) of MUC4
6) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.11 Pain Relevance 0.23
Recent published data about the MUC4 expression on protein level including samples from all PanIN grades and 25 invasive pancreatic adenocarcinoma detected MUC4 in all PanIN grades but with increasing percentage in PanIN-3 lesions (11/13) compared to PanIN-1 (5/30), PanIN-2 (10/28) [29]. 89% of the investigated DACs were MUC4 postive [29].
Gene_expression (expression) of MUC4 associated with adenocarcinoma
7) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.27 Pain Relevance 0.39
In addition to its involvement in the covering of luminal epithelia, recent studies suggest that the overexpression of the MUC4 rat homologue sialomucin complex (SMC) disrupts integrin-mediated cell-matrix and cell-cell interaction and inhibits immune recognition [33].
Gene_expression (overexpression) of MUC4 in covering
8) Confidence 0.75 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.73 Pain Relevance 0.06
MUC4, also a transmembrane mucin, is expressed by corneal as well as conjunctival epithelia.
Gene_expression (expressed) of MUC4
9) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.09 Pain Relevance 0
The ocular surface epithelium expresses at least four major mucin genes: MUCIN 1 (MUC1), MUCIN 4 (MUC4), MUCIN 5AC (MUC5AC), and MUCIN 16 (MUC16).
Gene_expression (expresses) of MUCIN 4 in surface epithelium
10) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.10 Pain Relevance 0
The ocular surface epithelium expresses at least four major mucin genes: MUCIN 1 (MUC1), MUCIN 4 (MUC4), MUCIN 5AC (MUC5AC), and MUCIN 16 (MUC16).
Gene_expression (expresses) of MUC4 in surface epithelium
11) Confidence 0.73 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994764 Disease Relevance 0.10 Pain Relevance 0
Indeed, a substantial number of tumor tissue samples (12 of 16) and tumor cell lines (11 of 15) expressed MUC4 mRNA, whereas samples from chronic pancreatitis (0 of 10) and the normal pancreas (0 of 7) tissues failed to exhibit any detectable level of this mucin.
Gene_expression (expressed) of MUC4 in pancreas
12) Confidence 0.67 Published 2001 Journal Clin. Cancer Res. Section Body Doc Link 11751498 Disease Relevance 0.29 Pain Relevance 0
Increasing expression of MUC4 with an increasing grade of PanIN supports the assumption of PanIN being a precursor for infiltrating pancreatic ductal adenocarcinoma.
Gene_expression (expression) of MUC4 associated with adenocarcinoma
13) Confidence 0.66 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.17 Pain Relevance 0.16
Normal pancreatic ducts do not express MUC4.
Neg (not) Gene_expression (express) of MUC4 in pancreatic ducts
14) Confidence 0.66 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.21 Pain Relevance 0.15
Our unpublished data, however, shows that MUC4 is expressed in ductal cells of chronic pancreatitis.
Gene_expression (expressed) of MUC4 associated with chronic pancreatitis
15) Confidence 0.66 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.14 Pain Relevance 0.19
A recent study on 71 PanIN lesions of different grades and 28 invasive carcinomas shows a steady increase in MUC4 expression along with the increase in severity of pancreatic duct lesion [67,68].
Gene_expression (expression) of MUC4 in pancreatic duct associated with carcinoma
16) Confidence 0.66 Published 2003 Journal Mol Cancer Section Body Doc Link PMC151686 Disease Relevance 1.22 Pain Relevance 0.13
Among the most differentially expressed genes identified by PCA were Mesothelin, Muc4, Muc5A/C, Kallikrein 10, Transglutaminase 2, Fascin, TMPRSS3 and stratifin.
Gene_expression (expressed) of Muc4
17) Confidence 0.66 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14695172 Disease Relevance 0.80 Pain Relevance 0
Beside the expression of the full length precursor of MUC4 (sv0-MUC4) with the soluble glycoprotein subunit MUC4?
Gene_expression (expression) of MUC4
18) Confidence 0.65 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.13 Pain Relevance 0.23
pancreatic cancer cells express MUC4 various splice variants [30,31].
Gene_expression (express) of MUC4 associated with pancreatic cancer
19) Confidence 0.65 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 1.06 Pain Relevance 0.21
Studies revealed that IPMNs in general express MUC2, MUC5AC and mostly MUC4 whereas MUC1 is absent [36-39].
Neg (absent) Gene_expression (express) of MUC4
20) Confidence 0.65 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149423 Disease Relevance 0.88 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox