INT10006

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Context Info
Confidence 0.23
First Reported 1982
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.56
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
brain 1
nucleus 1
ventral cord 1
brainstem 1
spleen 1
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 38 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
narcan 5 100.00 Very High Very High Very High
withdrawal 2 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Somatostatin 3 99.84 Very High Very High Very High
substance P 5 99.18 Very High Very High Very High
medulla 5 99.08 Very High Very High Very High
opiate 1 97.36 Very High Very High Very High
tolerance 1 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 13 100.00 Very High Very High Very High
Fever 6 100.00 Very High Very High Very High
Stress 6 99.98 Very High Very High Very High
Headache 5 96.64 Very High Very High Very High
Ganglion Cysts 2 94.04 High High
Nociception 1 88.12 High High
Hypoxia 8 87.12 High High
Disease 11 85.92 High High
Demyelinating Disease 19 83.64 Quite High
Oxidative Phosphorylation Disease 25 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal stress alters the hypothalamic levels of methionine-enkephalin in pup rats.
Regulation (alters) of methionine-enkephalin associated with stress and enkephalin
1) Confidence 0.23 Published 1992 Journal Neuropeptides Section Title Doc Link 1454153 Disease Relevance 0.52 Pain Relevance 0.41
In tissues of morphine- and U-50,488H-tolerant-dependent and abstinent rats methionine-enkephalin concentrations were affected differentially, suggesting inherent differences in mu- and kappa-opiate-mediated tolerance-dependence and abstinence processes.
Regulation (affected) of methionine-enkephalin associated with addiction, tolerance, opiate, enkephalin and morphine
2) Confidence 0.21 Published 1994 Journal Pharmacology Section Abstract Doc Link 8177908 Disease Relevance 0 Pain Relevance 1.05
In 3-day-old rabbits, exposure to 10% O2 did not affect methionine-enkephalin concentrations in any brainstem nuclei studied.
Neg (not) Regulation (affect) of methionine-enkephalin in brainstem associated with medulla and enkephalin
3) Confidence 0.16 Published 1986 Journal Pediatr. Res. Section Abstract Doc Link 3725463 Disease Relevance 0.55 Pain Relevance 0.66
The effects of hyperthermia induced seizures on the amount of Methionine-enkephalin (Met-E) in 15 day rat pups were examined.
Spec (examined) Regulation (effects) of Methionine-enkephalin associated with convulsion, enkephalin and fever
4) Confidence 0.15 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630599 Disease Relevance 0.57 Pain Relevance 0.17
Hyperthermia-induced seizures alter the levels of methionine-enkephalin in immature rat brain.
Regulation (alter) of methionine-enkephalin in brain associated with convulsion, enkephalin and fever
5) Confidence 0.09 Published 1992 Journal Neuropeptides Section Title Doc Link 1630599 Disease Relevance 0.64 Pain Relevance 0.20
Reserpine and tetrabenazine depleted 5-HT and partially depleted substance P and TRH in the ventral cord, but had no effect on either methionine-enkephalin or somatostatin. 5.
Neg (no) Regulation (effect) of methionine-enkephalin in ventral cord associated with somatostatin, enkephalin and substance p
6) Confidence 0.08 Published 1982 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Section Abstract Doc Link 6183051 Disease Relevance 0 Pain Relevance 0.65
The effect of chronic administration of morphine and abrupt and naloxone-precipitated withdrawal on the levels of beta-endorphin and methionine-enkephalin in spleen, adrenals and thymus glands of Sprague-Dawley rats was determined.
Regulation (effect) of methionine-enkephalin in spleen associated with narcan, enkephalin, withdrawal and morphine
7) Confidence 0.08 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 0.80
The methionine enkephalin (ME) induced responses of prolactin (PRL) and luteinizing hormone (LH) were studied in control and castrated rats bearing chronically-implanted cannulae in the right lateral ventricle.
Regulation (responses) of methionine enkephalin in lateral ventricle associated with enkephalin
8) Confidence 0.03 Published 1982 Journal Horm. Metab. Res. Section Abstract Doc Link 7068102 Disease Relevance 0 Pain Relevance 0.49
[Implication of the neuropeptides methionine enkephalin, neurotensin and somatostatin of the caudal trigeminal nucleus in the experimental migraine].
Regulation ([Implication) of methionine enkephalin in nucleus associated with migraine, somatostatin, neuropeptide and enkephalin
9) Confidence 0.02 Published 2002 Journal Rev Neurol Section Title Doc Link 12080490 Disease Relevance 0.46 Pain Relevance 0.72
In addition, we found high ADC and decreased MTR an FA values in the abnormal white matter.
Regulation (values) of MTR in white matter
10) Confidence 0.01 Published 2009 Journal Neuroradiology Section Body Doc Link PMC2744817 Disease Relevance 0.82 Pain Relevance 0.27

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