INT100079

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.26
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Arrb2) cytoplasmic membrane-bounded vesicle (Arrb2) plasma membrane (Arrb2)
nucleus (Arrb2) intracellular (Arrb2) cytoplasm (Arrb2)
Anatomy Link Frequency
neurons 2
locus coeruleus 2
hippocampus 2
Arrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 29 99.84 Very High Very High Very High
analgesia 6 99.84 Very High Very High Very High
Morphine 42 99.64 Very High Very High Very High
Hippocampus 4 98.48 Very High Very High Very High
methadone 3 97.92 Very High Very High Very High
opioid receptor 6 97.34 Very High Very High Very High
Locus ceruleus 2 97.32 Very High Very High Very High
mu opioid receptor 3 95.56 Very High Very High Very High
antinociception 3 95.48 Very High Very High Very High
Dopamine 1 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 29 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of beta-arrestin 2 associated with central grey, analgesia and morphine
1) Confidence 0.63 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16563622 Disease Relevance 0.68 Pain Relevance 1.34
In locus coeruleus, both acute and chronic morphine treatments resulted in significant decreases (over 50%) in beta-arrestin 1 mRNA level but failed to induce any change in the level of beta-arrestin 2 gene expression.
Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of beta-arrestin 2 in locus coeruleus associated with locus ceruleus and morphine
2) Confidence 0.61 Published 2003 Journal Neuroscience Section Abstract Doc Link 12614678 Disease Relevance 0.17 Pain Relevance 1.22
Compared with group M, the expressions of beta-arrestin 2 mRNA and protein were significantly elevated in group MF2 and MF3 (P < 0.05 or 0.01), but there was no significant change in group MF1 (P > 0.05).
Positive_regulation (elevated) of Gene_expression (expressions) of beta-arrestin 2 mRNA
3) Confidence 0.59 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19615194 Disease Relevance 0 Pain Relevance 0
We identified elevated expression of the beta-arrestin 2 gene (Arrb2) in the striatum and the hippocampus of ethanol-preferring AA rats compared to their nonpreferring counterpart ANA line.
Positive_regulation (elevated) of Gene_expression (expression) of beta-arrestin 2 in hippocampus associated with hippocampus
4) Confidence 0.56 Published 2008 Journal FASEB J. Section Abstract Doc Link 18367649 Disease Relevance 0 Pain Relevance 0.22
In the present study beta-arrestin 2 overexpression was induced by adenovirus at PAG of rats.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta-arrestin 2 associated with central grey
5) Confidence 0.55 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16563622 Disease Relevance 0.70 Pain Relevance 1.35
CONCLUSION: Fentanyl at 6 and 12 microg/kg can partly inhibit morphine tolerance through an increased expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of morphine-tolerant rats.


Positive_regulation (increased) of Gene_expression (expression) of beta-arrestin 2
6) Confidence 0.43 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19615194 Disease Relevance 0 Pain Relevance 0
In the present study beta-arrestin 2 overexpression was induced by adenovirus at PAG of rats.
Positive_regulation (induced) of Gene_expression (overexpression) of beta-arrestin 2 associated with central grey
7) Confidence 0.37 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16563622 Disease Relevance 0.71 Pain Relevance 1.36
Chronic treatment with DAMGO or methadone produced internalization of enhanced yellow fluorescent protein-tagged MOR expressed in hippocampal neurons within hours, whereas morphine produced internalization much more slowly, even when accompanied by overexpression of beta-arrestin-2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta-arrestin-2 in neurons associated with opioid receptor, methadone and morphine
8) Confidence 0.32 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11752206 Disease Relevance 0 Pain Relevance 1.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox