INT100085

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Context Info
Confidence 0.30
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CRHR2) signal transducer activity (CRHR2)
CRHR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 5 92.08 High High
Central nervous system 1 92.04 High High
antagonist 2 91.36 High High
5HT 1 79.52 Quite High
spastic colon 4 58.04 Quite High
nud 3 43.76 Quite Low
amygdala 1 32.88 Quite Low
Disease Link Frequency Relevance Heat
Stress 19 96.80 Very High Very High Very High
Carcinoid 1 78.64 Quite High
Gastrointestinal Disease 1 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 58.04 Quite High
Dyspepsia 1 43.76 Quite Low
Sensation Disorders 1 38.00 Quite Low
Functional Bowel Disorder 2 34.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of gastric emptying by CRF may be mediated by interaction with the CRF-2 receptor, while CRF-1 receptors are involved in the colonic and anxiogenic responses to stress.
CRF-2 receptor Binding (interaction) of associated with stress
1) Confidence 0.30 Published 2001 Journal Dig Dis Section Abstract Doc Link 11752838 Disease Relevance 1.05 Pain Relevance 0.19
The CRF1/2 ligand, rat/human (r/h)CRF (EC50 = 233 nM), and the selective CRF2 ligand, human urocortin 3 (Ucn 3) (EC50 = 48 nM), induced a dose-dependent increase in cAMP formation.
CRF2 Binding (induced) of
2) Confidence 0.02 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17184738 Disease Relevance 0.08 Pain Relevance 0.20

General Comments

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