INT100086

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.92
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
macrophages 2
muscle 2
nucleus 2
lung 2
midbrain 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 238 100.00 Very High Very High Very High
cytokine 186 100.00 Very High Very High Very High
agonist 27 99.98 Very High Very High Very High
midbrain 8 99.98 Very High Very High Very High
chemokine 90 99.84 Very High Very High Very High
tolerance 10 89.36 High High
Inflammatory response 45 86.76 High High
Substantia nigra 42 84.56 Quite High
Dopamine 32 84.32 Quite High
antagonist 32 83.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 231 100.00 Very High Very High Very High
Injury 86 100.00 Very High Very High Very High
Pulmonary Disease 24 100.00 Very High Very High Very High
Cancer 105 99.24 Very High Very High Very High
Necrosis 16 99.00 Very High Very High Very High
Pneumonia 65 98.56 Very High Very High Very High
Pseudomonas Infection 22 95.36 Very High Very High Very High
Metastasis 46 94.80 High High
Sepsis 137 94.44 High High
Skin Cancer 10 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR4 ligand decreased thermal injury-induced bacterial translocation
Negative_regulation (decreased) of Localization (translocation) of TLR4 associated with injury
1) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.13 Pain Relevance 0
Studies by Haziot et al. [10] and Stelter et al. [11] revealed that high concentrations of sCD14 can inhibit LPS-induced secretion of TNF by macrophages, which may result from transfer of LPS to lipoproteins and subsequent removal [7].
Negative_regulation (inhibit) of Localization (secretion) of LPS in macrophages
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.17 Pain Relevance 0.12
A secretory form of TLR4 has been described in mice, where the soluble TLR4 appears to inhibit LPS mediated signals, while at the same time sTLR4 mRNA is upregulated by LPS[43].
Negative_regulation (described) of Localization (secretory) of TLR4
3) Confidence 0.34 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1351185 Disease Relevance 0.15 Pain Relevance 0.04
PLGA-PEGPS341 inhibits P. aeruginosa LPS induced CF lung disease
Negative_regulation (inhibits) of Localization (disease) of LPS in lung associated with pulmonary disease
4) Confidence 0.33 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 1.24 Pain Relevance 0.14
Moreover, AA significantly and dose-dependently reduced intracellular increase of four pro-inflammatory cytokines in LPS treated samples as seen in Figure 4 (B).
Negative_regulation (reduced) of Localization (increase) of LPS associated with inflammation and cytokine
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.22 Pain Relevance 0.42
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Negative_regulation (supported) of Localization (translocation) of TLR4 in nucleus
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.36 Pain Relevance 0.12
Furthermore, EGCG dramatically inhibited LPS-induced release of IL-6, and a number of chemokines including MIP-1?
Negative_regulation (inhibited) of Localization (release) of LPS associated with chemokine
7) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.08 Pain Relevance 0.29
Furthermore, EGCG dramatically inhibited LPS-induced release of IL-6, and a number of chemokines including MIP-1?
Negative_regulation (number) of Localization (release) of LPS associated with chemokine
8) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2048740 Disease Relevance 0.08 Pain Relevance 0.29
Therefore, we hypothesized that excessive IL-6 expression decreased LPS-induced neutrophil emigration in p50-deficient mice.
Negative_regulation (decreased) of Localization (emigration) of LPS in neutrophil
9) Confidence 0.18 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.23 Pain Relevance 0.23
In addition, the same A2A agonist reduced LPS-induced microvascular permeability and secretion of interleukin-6, tumor necrosis factor-?
Negative_regulation (reduced) of Localization (secretion) of LPS associated with necrosis, cancer and agonist
10) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.05 Pain Relevance 0.44
Interestingly, both CCR1 and CCR5 were significantly upregulated in the TA muscle at 6 hours after LPS administration.
Negative_regulation (hours) of Localization (administration) of LPS in muscle
11) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.15 Pain Relevance 0.04
M) significantly reduced the migration of LPS-stimulated microglia towards ADP (85 ± 4 vs. 24 ± 4 cells LPS alone and LPS plus minocycline groups respectively, p < 0.05, data not shown).
Negative_regulation (reduced) of Localization (migration) of LPS in microglia
12) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.08
Microglia activation in the ventral midbrain following administration of LPS and 6-OHDA
Negative_regulation (following) of Localization (administration) of LPS in midbrain associated with midbrain
13) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.06 Pain Relevance 0.26
The fact that isoproterenol decreased the LPS-induced TNF-alpha release, whereas propranolol augmented basal and LPS-induced release suggests that the sympathetic nervous system inhibits basal and LPS-stimulated TNF-alpha release via beta-adrenergic receptors.
Negative_regulation (decreased) of Localization (release) of LPS in sympathetic nervous system
14) Confidence 0.01 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11752888 Disease Relevance 0 Pain Relevance 0
Isoproterenol, a beta-adrenergic agonist, also blocked LPS-induced TNF-alpha release by 70% at 30 min and 90% at 120 min.
Negative_regulation (blocked) of Localization (release) of LPS
15) Confidence 0.01 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11752888 Disease Relevance 0 Pain Relevance 0

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