INT10009

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 8.94
Pain Relevance 11.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
afferent neurons 4
pituitary 3
thyroid 2
cerebrospinal fluid 2
unspecified 1
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 2 100.00 Very High Very High Very High
Somatostatin 21 99.90 Very High Very High Very High
gABA 10 99.84 Very High Very High Very High
withdrawal 4 99.76 Very High Very High Very High
Calcitonin gene-related peptide 24 99.74 Very High Very High Very High
depression 31 99.72 Very High Very High Very High
nMDA receptor 3 99.48 Very High Very High Very High
dexamethasone 3 99.48 Very High Very High Very High
Morphine 5 99.32 Very High Very High Very High
anesthesia 4 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 40 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.64 Very High Very High Very High
Starvation 4 99.08 Very High Very High Very High
Hypopituitarism 5 98.24 Very High Very High Very High
Urological Neuroanatomy 5 97.60 Very High Very High Very High
Injury 7 97.08 Very High Very High Very High
Epilepsy 11 97.02 Very High Very High Very High
Disease 22 96.82 Very High Very High Very High
Spinal Injuries 2 96.16 Very High Very High Very High
Acromegaly 83 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical investigations, following performance of neuroadenolysis, indicate suppressed pituitary function, significant increase of ACTH, thyrotropin-releasing hormone and vasopressin in the cerebrospinal fluid (CSF), delay of long latencies in somatosensory evoked potential and increased pain threshold of C-fibres.
Positive_regulation (increase) of thyrotropin-releasing hormone in cerebrospinal fluid associated with c fibre and pain threshold
1) Confidence 0.67 Published 1986 Journal Neurol. Res. Section Abstract Doc Link 2433639 Disease Relevance 0.87 Pain Relevance 0.74
We conclude that the facilitatory effect of TRH on avoidance retention and retrieval may be mediated by NMDA receptors.
Positive_regulation (effect) of TRH associated with nmda receptor
2) Confidence 0.50 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1454156 Disease Relevance 0.07 Pain Relevance 0.17
In Huntington's disease, there are reduced concentrations of substance P, met-enkephalin and cholecystokinin in the basal ganglia; in contrast the concentrations of somatostatin and TRH are increased.
Positive_regulation (increased) of TRH in basal ganglia associated with somatostatin, enkephalin, disease, cholecystokinin and substance p
3) Confidence 0.49 Published 1984 Journal Peptides Section Abstract Doc Link 6207511 Disease Relevance 0.50 Pain Relevance 0.48
The involvement of capsaicin-sensitive afferent neurons and calcitonin gene-related peptide (CGRP) in the central thyrotropin-releasing hormone (TRH)-induced hepatic hyperemia was investigated in urethane anesthetized rats.
Positive_regulation (-induced) of TRH in afferent neurons associated with qutenza, increased venous pressure under development and calcitonin gene-related peptide
4) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10513557 Disease Relevance 0.17 Pain Relevance 0.63
The involvement of capsaicin-sensitive afferent neurons and calcitonin gene-related peptide (CGRP) in the central thyrotropin-releasing hormone (TRH)-induced hepatic hyperemia was investigated in urethane anesthetized rats.
Positive_regulation (-induced) of thyrotropin-releasing hormone in afferent neurons associated with qutenza, increased venous pressure under development and calcitonin gene-related peptide
5) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10513557 Disease Relevance 0.17 Pain Relevance 0.63
The involvement of capsaicin-sensitive afferent neurons and calcitonin gene-related peptide (CGRP) in central thyrotropin-releasing hormone (TRH)-induced hepatic cytoprotection was investigated in rats.
Positive_regulation (-induced) of thyrotropin-releasing hormone in afferent neurons associated with qutenza and calcitonin gene-related peptide
6) Confidence 0.49 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575802 Disease Relevance 0.07 Pain Relevance 0.63
The involvement of capsaicin-sensitive afferent neurons and calcitonin gene-related peptide (CGRP) in central thyrotropin-releasing hormone (TRH)-induced hepatic cytoprotection was investigated in rats.
Positive_regulation (-induced) of TRH in afferent neurons associated with qutenza and calcitonin gene-related peptide
7) Confidence 0.49 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575802 Disease Relevance 0.07 Pain Relevance 0.63
The accumulation of immunoreactive proTRH-derived peptides, but not the mature TRH tripeptide was concomitantly observed in these cells.
Positive_regulation (accumulation) of TRH
8) Confidence 0.49 Published 1996 Journal Brain Res. Section Abstract Doc Link 8874872 Disease Relevance 0.44 Pain Relevance 0.69
In order to gain insight into the neuroendocrine mechanism underlying the paradoxical GH response to TRH in acromegalic patients, we have investigated the effect of an infusion of Naloxone (Nal, 1.6 mg/hr for two hours), on a TRH test performed both in responder (n = 9) and non-responder (n = 5) acromegalic patients.
Positive_regulation (response) of TRH associated with narcan
9) Confidence 0.49 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8750573 Disease Relevance 0 Pain Relevance 0.17
Six animals each received thyrotropin-releasing hormone, saline, or dexamethasone as an intravenous infusion over four hours, beginning one hour after injury.
Positive_regulation (received) of thyrotropin-releasing hormone associated with injury and dexamethasone
10) Confidence 0.49 Published 1981 Journal N. Engl. J. Med. Section Abstract Doc Link 6792542 Disease Relevance 0.73 Pain Relevance 0.58
No significant variations of TSH, T4, T3 and rT3 levels were documented, either in basal conditions or after TRH stimulation; however a reduced TSH pituitary response was recorded in some patients (6 out of 15).
Positive_regulation (stimulation) of TRH in pituitary
11) Confidence 0.49 Published 1984 Journal Horm. Metab. Res. Section Abstract Doc Link 6698493 Disease Relevance 0 Pain Relevance 0.17
BACKGROUND: Starvation is associated with a blunted TSH response to thyrotropin-releasing hormone (TRH) (peak minus baseline < 5 mIU/L), despite basal TSH and thyroid hormone levels within the normal range.
Positive_regulation (response) of thyrotropin-releasing hormone in thyroid associated with starvation
12) Confidence 0.49 Published 1999 Journal J. Investig. Med. Section Abstract Doc Link 10361382 Disease Relevance 0.17 Pain Relevance 0.16
Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.
Positive_regulation (-induced) of thyrotropin-releasing hormone associated with anesthesia and halothane
13) Confidence 0.49 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1906092 Disease Relevance 0 Pain Relevance 0.42
Halothane, at concentrations used to produce general anesthesia in animals (0.25-0.76 mM), inhibited thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) secretion.
Positive_regulation (-induced) of TRH associated with anesthesia and halothane
14) Confidence 0.49 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1906092 Disease Relevance 0 Pain Relevance 0.42
In response to TRH (200 micrograms, iv), PRL levels increased by 493 +/- 86% (mean +/- SE) over basal levels.
Positive_regulation (increased) of TRH
15) Confidence 0.49 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2118537 Disease Relevance 0.14 Pain Relevance 0.24
Measuring the serum prolactin level after giving thyrotropin-releasing hormone is a reasonable first step in the diagnosis of this condition in patients who fail to lactate after giving birth.
Positive_regulation (giving) of thyrotropin-releasing hormone
16) Confidence 0.49 Published 1989 Journal Emerg. Med. Clin. North Am. Section Abstract Doc Link 2680471 Disease Relevance 1.11 Pain Relevance 0.10
A similar period of GH refractoriness to TRH or hpGRF stimulation was also observed in adult birds, although the recovery of GH responsiveness occurred earlier.
Positive_regulation (stimulation) of TRH
17) Confidence 0.48 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
Similarly, prior exposure to hpGRF also increased the GH response to TRH stimulation (by 2.24-fold in the young, 3.56-fold in the adults).
Positive_regulation (stimulation) of TRH
18) Confidence 0.48 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926600 Disease Relevance 0 Pain Relevance 0
In conclusion, the PRL response to TRH may be unaffected by endogenous opioids or naloxone and we were unable to reveal a possible opioid effect in our experimental conditions.
Positive_regulation (response) of TRH associated with narcan, endogenous opioid and opioid
19) Confidence 0.47 Published 1989 Journal Minerva Endocrinol. Section Abstract Doc Link 2503692 Disease Relevance 0 Pain Relevance 0.50
TSH response to TRH seems to be affected by endogenous opioids, possibly due to an indirect or direct action on TRH and/or on the pituitary.
Positive_regulation (response) of TRH in pituitary associated with endogenous opioid
20) Confidence 0.47 Published 1989 Journal Minerva Endocrinol. Section Abstract Doc Link 2503692 Disease Relevance 0 Pain Relevance 0.51

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