INT100096

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 1
Speculated 7
Reported most in Abstract
Documents 24
Total Number 31
Disease Relevance 7.25
Pain Relevance 12.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
brain 5
hippocampus 3
cortex 2
raphe nucleus 2
neurons 1
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 717 100.00 Very High Very High Very High
Serotonin 344 100.00 Very High Very High Very High
cocaine 13 99.68 Very High Very High Very High
sSRI 715 99.48 Very High Very High Very High
antidepressant 244 99.40 Very High Very High Very High
Raphe 109 99.40 Very High Very High Very High
Hippocampus 63 99.24 Very High Very High Very High
Kinase C 60 98.80 Very High Very High Very High
Dopamine 87 98.00 Very High Very High Very High
Desipramine 3 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 15 99.40 Very High Very High Very High
Targeted Disruption 54 98.60 Very High Very High Very High
Hypoxia 5 98.24 Very High Very High Very High
Schizophrenia 2 98.12 Very High Very High Very High
Coronary Heart Disease 12 97.76 Very High Very High Very High
Dilated Cardiomyopathy 48 97.20 Very High Very High Very High
Neurodegenerative Disease 35 97.04 Very High Very High Very High
Anxiety Disorder 136 96.76 Very High Very High Very High
Congenital Anomalies 60 96.20 Very High Very High Very High
Depression 323 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study.
Regulation (effect) of serotonin transporter in hippocampus associated with hippocampus and serotonin
1) Confidence 0.62 Published 2005 Journal Brain Res. Section Title Doc Link 16298349 Disease Relevance 0.54 Pain Relevance 0.52
The sex steroid hormone estrogen is known to modulate functional SERT activity, but whether it is up- or down-regulated is unclear.
Regulation (modulate) of SERT
2) Confidence 0.54 Published 2005 Journal Brain Res. Section Abstract Doc Link 16298349 Disease Relevance 0.43 Pain Relevance 0.37
We report here the effects of chronic fluoxetine treatment and genetic deletion of the serotonin transporter (SERT) on food reinforced behavior in three paradigms: the progressive ratio operant task, the concurrent choice operant task, and the Pavlovian-to-Instrumental transfer task.
Regulation (effects) of SERT associated with serotonin and fluoxetine
3) Confidence 0.45 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17356573 Disease Relevance 0 Pain Relevance 0.34
We report here the effects of chronic fluoxetine treatment and genetic deletion of the serotonin transporter (SERT) on food reinforced behavior in three paradigms: the progressive ratio operant task, the concurrent choice operant task, and the Pavlovian-to-Instrumental transfer task.
Regulation (effects) of serotonin transporter associated with serotonin and fluoxetine
4) Confidence 0.45 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17356573 Disease Relevance 0 Pain Relevance 0.34
Effects of serotonin transporter inhibition on gastrointestinal motility and colonic sensitivity in the mouse.
Regulation (Effects) of serotonin transporter associated with serotonin
5) Confidence 0.45 Published 2006 Journal Neurogastroenterol. Motil. Section Title Doc Link 16700726 Disease Relevance 0.42 Pain Relevance 0.41
On day 28 brains were analysed for serotonin transporter (SERT) density in cortex and noradrenaline transporter (NET) density in cortex and hippocampus.
Spec (analysed) Regulation (analysed) of serotonin transporter in cortex
6) Confidence 0.45 Published 2007 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 17335951 Disease Relevance 0 Pain Relevance 0
On day 28 brains were analysed for serotonin transporter (SERT) density in cortex and noradrenaline transporter (NET) density in cortex and hippocampus.
Spec (analysed) Regulation (analysed) of SERT in cortex
7) Confidence 0.45 Published 2007 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 17335951 Disease Relevance 0 Pain Relevance 0
The effects of serotonin transporter inhibitors on PH in humans deserve investigation.
Regulation (effects) of serotonin transporter associated with hypertension and serotonin
8) Confidence 0.45 Published 2003 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12773327 Disease Relevance 0.63 Pain Relevance 0.41
In situ hybridization showed no changes in 5-HT(2A) receptor and serotonin transporter mRNA levels, whereas 5-HT(2C) receptor mRNA levels were reduced in certain brain regions.
Regulation (changes) of serotonin transporter mRNA in brain associated with serotonin
9) Confidence 0.44 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754082 Disease Relevance 0.15 Pain Relevance 0.32
The effect of two psychotropics and one narcotic on the binding of [(123)I]ADAM to SERT was also studied.
Regulation (effect) of SERT
10) Confidence 0.40 Published 2004 Journal Nucl. Med. Biol. Section Abstract Doc Link 15219272 Disease Relevance 0 Pain Relevance 0.42
These data rule out the involvement of accumbal NET or SERT in the cocaine-induced increase in extracellular DA in DAT-KO mice.
Regulation (involvement) of SERT associated with dopamine and cocaine
11) Confidence 0.33 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12006604 Disease Relevance 0.15 Pain Relevance 1.18
Candidate genes for these association analyses, selected from known and putative pathways of SSRI action, include polymorphisms affecting the serotonin transporter, serotonin receptors, intracellular transduction, the HPA axis, BDNF and neurogenesis, and other neurotransmitter systems.
Regulation (affecting) of serotonin transporter associated with neurotransmitter, neurodegenerative disease, serotonin and ssri
12) Confidence 0.31 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.10 Pain Relevance 0.24
Quantitative receptor autoradiography was used to study possible alterations of the densities of multiple serotonin (5-HT) receptor subtypes and of serotonin transporter in the brain of 5-HT(2C) receptor knockout mice.
Regulation (alterations) of serotonin transporter in brain associated with targeted disruption and serotonin
13) Confidence 0.27 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754082 Disease Relevance 0.17 Pain Relevance 0.26
We show that SERT is a target of microRNA-16 (miR-16). miR-16 is expressed at higher levels in noradrenergic than in serotonergic cells; its reduction in noradrenergic neurons causes de novo SERT expression.
Regulation (target) of SERT in neurons
14) Confidence 0.26 Published 2010 Journal Science Section Abstract Doc Link 20847275 Disease Relevance 0 Pain Relevance 0.62
In order to examine the interplay between 5HT1A receptors and dynamic SERT regulation in the presence of SSRIs, we plan to extend our model to include the cell body of the serotonergic cell.
Spec (examine) Regulation (regulation) of SERT in cell body associated with ssri
15) Confidence 0.25 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0 Pain Relevance 0.25
To determine if Sert is a direct transcriptional target of Zic2, we investigated whether this transcription factor activates Sert regulatory sequences.
Regulation (target) of Sert
16) Confidence 0.23 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
In addition to other activities, PP2A can exist in close relationship with the SERT protein and is involved in regulating SERT’s activity (Bauman et al 2000).
Regulation (regulating) of SERT
17) Confidence 0.20 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0 Pain Relevance 0.15
In the RTN/pFRG of neonatal rats, SERT immunoreactivity and 5-HT receptors expression has been reported, such a dense 5-HT innervation forming a possible anatomical substrate for 5HT-dependent control of RTN/pFRG chemoreceptors [27]–[29].
Regulation (immunoreactivity) of SERT associated with 5ht
18) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.22 Pain Relevance 0.36
The decay time back to baseline depends of course on the Vmax of the SERTs, which in turn depends on the SERT density that is quite different in different brain regions.
Regulation (depends) of SERT in brain
19) Confidence 0.18 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2942809 Disease Relevance 0 Pain Relevance 0.16
Molecular analysis of fluoxetine-exposed offspring showed long-term alterations in serotonin transporter levels in the raphe nucleus.
Regulation (alterations) of serotonin transporter in raphe nucleus associated with raphe, serotonin and fluoxetine
20) Confidence 0.18 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2518512 Disease Relevance 0.55 Pain Relevance 1.07

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