INT100097

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
brain 2
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 9 100.00 Very High Very High Very High
Serotonin 6 99.14 Very High Very High Very High
c fibre 17 94.72 High High
Sumatriptan 1 77.60 Quite High
Opioid 1 25.00 Low Low
Nerve growth factor 29 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 22 5.00 Very Low Very Low Very Low
nociceptor 19 5.00 Very Low Very Low Very Low
substance P 8 5.00 Very Low Very Low Very Low
Neuropeptide 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 1 89.36 High High
Targeted Disruption 16 75.00 Quite High
Ganglion Cysts 66 50.00 Quite Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 6 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization showed no changes in 5-HT(2A) receptor and serotonin transporter mRNA levels, whereas 5-HT(2C) receptor mRNA levels were reduced in certain brain regions.
Negative_regulation (reduced) of Transcription (levels) of receptor in brain associated with serotonin
1) Confidence 0.03 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 11754082 Disease Relevance 0.15 Pain Relevance 0.31
Nitric oxide (NO) suppressed the transcription of the mouse kappa opioid receptor (KOR) gene, mediated by a rapid downregulation of c-myc gene expression.
Negative_regulation (suppressed) of Transcription (transcription) of receptor associated with kappa opioid receptor
2) Confidence 0.03 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.09 Pain Relevance 0.21
The mRNA levels for the putative mechanosensitive ion channels ASIC2a and 2b are increased, whereas transcript levels for the heat receptor TRPV1 are decreased.
Negative_regulation (decreased) of Transcription (levels) of receptor
3) Confidence 0.00 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.28

General Comments

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