INT100114

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Context Info
Confidence 0.73
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
ascending limb 1
optic nerves 1
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 96.08 Very High Very High Very High
antagonist 4 94.00 High High
imagery 1 46.72 Quite Low
headache 1 33.60 Quite Low
medulla 1 22.12 Low Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arachnoid Cysts 44 99.84 Very High Very High Very High
Cyst 40 96.40 Very High Very High Very High
Chronic Renal Failure 124 91.16 High High
Pressure And Volume Under Development 5 75.00 Quite High
Hypercalcemia 1 60.56 Quite High
Bartter Syndrome 1 56.56 Quite High
Head Trauma 1 54.56 Quite High
Hematoma 3 40.16 Quite Low
Convulsion 1 34.44 Quite Low
Dizziness 1 34.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also used a monoclonal antibody to the NKCC1 form of the Na-K-2Cl cotransporter to show that NKCC1 is expressed in optic nerves as shown in Western blotting and is colocalized in GFAP immunopositive astrocytes.
Localization (colocalized) of NKCC1 in optic nerves
1) Confidence 0.73 Published 2002 Journal Glia Section Abstract Doc Link 11754210 Disease Relevance 0.18 Pain Relevance 0.31
We have recently described the up-regulation of the CSF-secreting cation chloride co-transporter NKCC1 in AC membranes compared with normal arachnoid [8].
Localization (secreting) of NKCC1 associated with arachnoid cysts
2) Confidence 0.24 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2898803 Disease Relevance 1.37 Pain Relevance 0
The Na-K-2Cl cotransporter BSC-1, which is localized at the apical plasma membrane domains of medullary and cortical thick ascending limb segments, mediates the apical NaCl transport in these water-impermeable segments (6, 28).
Localization (localized) of BSC-1 in ascending limb
3) Confidence 0.16 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.47 Pain Relevance 0

General Comments

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