INT100124

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 38
Total Number 52
Disease Relevance 30.02
Pain Relevance 23.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
neurons 7
sensory neurons 4
DRG 4
muscle 3
dorsal root 2
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 71 99.96 Very High Very High Very High
Nav1.9 177 99.92 Very High Very High Very High
Nav1.6 21 99.92 Very High Very High Very High
Inflammation 1138 99.80 Very High Very High Very High
qutenza 123 99.78 Very High Very High Very High
Potency 14 99.78 Very High Very High Very High
Thermal hyperalgesia 92 99.64 Very High Very High Very High
trigeminal ganglion 150 99.60 Very High Very High Very High
Nav1.7 21 99.60 Very High Very High Very High
Root ganglion neuron 4 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 142 99.98 Very High Very High Very High
Ganglion Cysts 255 99.96 Very High Very High Very High
Nociception 64 99.92 Very High Very High Very High
INFLAMMATION 1179 99.80 Very High Very High Very High
Hyperalgesia 441 99.64 Very High Very High Very High
Pain 296 99.56 Very High Very High Very High
Acidosis 229 99.56 Very High Very High Very High
Granuloma 126 99.12 Very High Very High Very High
Aids-related Complex 112 99.12 Very High Very High Very High
Cancer 30 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsal root ganglion neurons innervating muscle express ASIC3 and respond to acidic pH with fast, transient inward and sustained currents that resemble those of ASICs.
Gene_expression (express) of ASIC3 in Dorsal root ganglion associated with ganglion cysts, root ganglion neuron and asic
1) Confidence 0.78 Published 2003 Journal Pain Section Abstract Doc Link 14659506 Disease Relevance 0.94 Pain Relevance 1.19
To further identify the precise location of ASIC3-containing afferents in inflamed sites, we stained frozen muscle sections with antibodies against ASIC3 and PGP9.5, which is an ubiqutin C-terminal hydrolase specifically expressed in most neurons [19].
Gene_expression (expressed) of ASIC3 in neurons
2) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 1.01 Pain Relevance 0.43
To investigate which genes might be involved in the development of hyperalgesia, we examined the transcript levels of ASIC3, Nav1.6, Nav1.7, Nav1.8, Nav1.9 and TRPV1 normalized to GAPDH in DRGs of mice 2 days after inflammation induction.
Gene_expression (levels) of ASIC3 associated with hyperalgesia, inflammation, nav1.8, nav1.7, nav1.6 and nav1.9
3) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 0.72 Pain Relevance 0.93
Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells.
Gene_expression (expressed) of acid-sensing ion channel 3
4) Confidence 0.77 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18466760 Disease Relevance 0.52 Pain Relevance 0.13
Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells.
Gene_expression (expressed) of ASIC3
5) Confidence 0.77 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18466760 Disease Relevance 0.52 Pain Relevance 0.13
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Gene_expression (expression) of ASIC3 associated with inflammation and ipn
6) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.18 Pain Relevance 1.01
This subunit specificity together with the restricted distribution pattern of ASIC3 [9] suggests that an AGM-dependent regulatory pathway most likely occurs in peripheral tissues expressing homomeric ASIC3 and/or heteromeric ASIC3 + 1b channels [8,36,58].
Gene_expression (expressing) of ASIC3
7) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.29 Pain Relevance 0.27
The hyperosmolarity (600 mosmol kg-1 with mannitol) itself did not induce any detectable current (Figure 3A) but significantly potentiated the ASIC3 currents evoked by a pH reduction to 7.0 (Figure 3), an effect previously observed in rat DRG neurons or an ASIC3 expressing F-11 DRG cell line [8].
Gene_expression (expressing) of ASIC3 in neurons
8) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.74 Pain Relevance 0.43
Conventional whole-cell patch clamp recordings were performed in Chinese Hamster Ovary (CHO) cell lines transiently expressing ASIC3 tagged with GFP to measure the functional activation of ASIC3 channels under voltage clamp conditions.
Gene_expression (expressing) of ASIC3 in Ovary
9) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.95 Pain Relevance 0.34
ASIC3-expressing CHO cells were exposed to AGM and mild acidosis in the absence or presence of hyperosmolarity (Figure 3).
Gene_expression (expressing) of ASIC3 associated with acidosis
10) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.75 Pain Relevance 0.49
ASIC3-expressing CHO cells were exposed to AGM and mild acidosis in the absence or presence of hyperosmolarity (Figure 3).
Gene_expression (-) of ASIC3 associated with acidosis
11) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.75 Pain Relevance 0.49
To understand the functional relevance of AGM-ASIC3 interaction, we examined the pH dependence of AGM action by applying graded pH to the CHO cell expressing ASIC3 channels, in the presence or absence of AGM (Figure 2A).
Gene_expression (expressing) of ASIC3 associated with addiction
12) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.81 Pain Relevance 0.29
However, much interest was aroused in ASICs as potential mechanosensors because they are highly expressed in sensory neurons and 2 isoforms (ASIC3 and 1b) are almost exclusively expressed in these cells.
Gene_expression (expressed) of ASIC3 in sensory neurons associated with asic
13) Confidence 0.75 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074358 Disease Relevance 0 Pain Relevance 0.31
We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation.
Spec (examined) Gene_expression (expression) of ASIC3 in muscle associated with ganglion cysts, inflammation and root ganglion neuron
14) Confidence 0.75 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.01 Pain Relevance 0.45
In contrast to whole DRG, FISH of colonic neurons showed ASIC3 expression in 73 +/- 2%, ASIC2 in 47 +/- 0.5%, and ASIC1 in 30 +/- 2%.
Gene_expression (expression) of ASIC3 in DRG
15) Confidence 0.75 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.36
ASIC1a and ASIC3, which are expressed in nociceptive neurons, have been implicated in inflammation and knockout mice studies support the role of ASIC3 in various pain processes.
Gene_expression (expressed) of ASIC3 in neurons associated with targeted disruption, nociception, pain and inflammation
16) Confidence 0.72 Published 2007 Journal Toxicon Section Abstract Doc Link 17113616 Disease Relevance 0.54 Pain Relevance 0.47
Large DRG neurons express the dorsal root acid sensing ion channel (DRASIC), suggesting that DRASIC might contribute to H+-gated DRG currents.
Gene_expression (express) of dorsal root acid sensing ion channel in dorsal root associated with dorsal root ganglion
17) Confidence 0.68 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12037186 Disease Relevance 0.55 Pain Relevance 0.28
Disrupting the mouse DRASIC gene altered sensory transduction in specific and distinct ways.
Gene_expression (Disrupting) of DRASIC gene
18) Confidence 0.68 Published 2001 Journal Neuron Section Abstract Doc Link 11754838 Disease Relevance 0.10 Pain Relevance 0.18
In CFA-inflamed muscle, no obvious ASIC3 or PGP9.5 immunoreactivities were found in areas surrounding granuloma (Fig. 9H–K).
Gene_expression (found) of ASIC3 in muscle associated with granuloma
19) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 0.89 Pain Relevance 0.61
Thus peripheral algogenic effects of NPSF cannot be explained only in terms of their action on the ASIC3 channels and involves some other, still unidentified mechanism.
Gene_expression (action) of ASIC3 associated with algogenic
20) Confidence 0.68 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16730827 Disease Relevance 0.32 Pain Relevance 0.42

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