INT100125

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.85
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
sensory neurons 1
muscle 1
neurons 1
brainstem 1
nociceptors 1
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 75 100.00 Very High Very High Very High
tolerance 1 99.60 Very High Very High Very High
medulla 13 99.56 Very High Very High Very High
dorsal root ganglion 19 99.36 Very High Very High Very High
Lasting pain 1 98.84 Very High Very High Very High
Hyperalgesia 10 98.66 Very High Very High Very High
aPETx2 4 98.02 Very High Very High Very High
PcTx1 3 98.00 Very High Very High Very High
Mechanosensation 4 94.96 High High
Neuropeptide 7 94.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 111 100.00 Very High Very High Very High
Deafness 18 100.00 Very High Very High Very High
Impaired Glucose Tolerance 4 99.92 Very High Very High Very High
Nociception 10 99.54 Very High Very High Very High
Pain 14 98.84 Very High Very High Very High
Hyperalgesia 10 98.66 Very High Very High Very High
Injury 14 96.92 Very High Very High Very High
Insulin Resistance 2 96.40 Very High Very High Very High
Targeted Disruption 57 96.12 Very High Very High Very High
Diabetes Mellitus 1 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.
Neg (not) Negative_regulation (loss) of ASIC3 in muscle associated with hyperalgesia
1) Confidence 0.59 Published 2003 Journal Pain Section Title Doc Link 14659506 Disease Relevance 0.91 Pain Relevance 1.00
Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.
Negative_regulation (inhibition) of ASIC3 associated with impaired glucose tolerance
2) Confidence 0.58 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 18466760 Disease Relevance 0.55 Pain Relevance 0.13
Our finding suggests that proton-sensing GPCRs could have some roles in nociception or in compensation of loss of ASIC3 gene.
Negative_regulation (loss) of ASIC3 gene associated with nociception
3) Confidence 0.46 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17720533 Disease Relevance 0.99 Pain Relevance 0.63
Loss of ASIC3, in contrast, results in an age-dependent hearing loss[17].
Negative_regulation (Loss) of ASIC3 associated with deafness
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.24 Pain Relevance 0
To test this, we examined whole cell currents in large DRG neurons from mice in which the DRASIC gene had been disrupted.
Negative_regulation (disrupted) of DRASIC gene in neurons associated with dorsal root ganglion
5) Confidence 0.43 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12037186 Disease Relevance 0.54 Pain Relevance 0.27
Recently, two peptides, PcTx1 and APETx2, isolated from a spider and a sea anemone, have been characterized as selective and high-affinity inhibitors for ASIC1a and ASIC3 channels, respectively.
Negative_regulation (inhibitors) of ASIC3 associated with pctx1 and apetx2
6) Confidence 0.40 Published 2007 Journal Toxicon Section Abstract Doc Link 17113616 Disease Relevance 0.49 Pain Relevance 0.83
In contrast, in studies of click-evoked auditory brainstem response (ABR), mice lacking Asic3 showed progressive hearing loss with age[17].
Negative_regulation (lacking) of Asic3 in brainstem associated with medulla and deafness
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.27 Pain Relevance 0.20
Hearing loss in Asic3?
Negative_regulation (loss) of Asic3 associated with deafness
8) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.10 Pain Relevance 0
Loss of DRASIC increased the sensitivity of mechanoreceptors detecting light touch, but it reduced the sensitivity of a mechanoreceptor responding to noxious pinch and decreased the response of acid- and noxious heat-sensitive nociceptors.
Negative_regulation (Loss) of DRASIC in nociceptors associated with nociceptor
9) Confidence 0.38 Published 2001 Journal Neuron Section Abstract Doc Link 11754838 Disease Relevance 0.10 Pain Relevance 0.20
The loss of DRASIC also altered but did not abolish the current potentiation generated by FMRF-related peptides.
Negative_regulation (loss) of DRASIC
10) Confidence 0.38 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12037186 Disease Relevance 0.52 Pain Relevance 0.26
Expression of the acid-sensing receptor Accn3/DRASIC, also found in a range of large and small sensory neurons in the TG [42], is Runx1-independent in the DRG and was markedly decreased in the Brn3a-/- TG (Figure 3B).
Negative_regulation (decreased) of Accn3 in sensory neurons associated with trigeminal ganglion
11) Confidence 0.29 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 1.14 Pain Relevance 0.81

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox