INT100126

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.73
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
muscle 2
skin 1
DRG 1
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 119 99.16 Very High Very High Very High
Hyperalgesia 49 98.24 Very High Very High Very High
Mechanosensation 3 95.96 Very High Very High Very High
ASIC 17 94.00 High High
medulla 8 83.48 Quite High
midbrain 8 82.40 Quite High
Nav1.6 3 82.16 Quite High
Nav1.7 3 81.52 Quite High
nav1.8 9 80.88 Quite High
Nav1.9 25 80.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 121 99.16 Very High Very High Very High
Hyperalgesia 63 98.24 Very High Very High Very High
Granuloma 18 97.48 Very High Very High Very High
Nociception 6 94.52 High High
Injury 13 80.64 Quite High
Increased Venous Pressure Under Development 19 72.76 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 69.92 Quite High
Rhabdomyolysis 2 67.64 Quite High
Targeted Disruption 11 67.24 Quite High
Hemorrhage 4 65.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
QPCR of whole thoracolumbar DRG revealed and abundance of ASIC2 > ASIC1 > ASIC3.
Localization (abundance) of ASIC3 in DRG
1) Confidence 0.77 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.34
In contrast, in carrageenan-inflamed muscle, the location of ASIC3 immunoreactivity was often found on vessels with vasuclitis (Fig. 9L–O).


Localization (location) of ASIC3 in muscle
2) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2632618 Disease Relevance 0.77 Pain Relevance 0.67
Thus, peripherally located ASIC1 and ASIC3 play different roles in the development of hyperalgesia after muscle inflammation.
Localization (located) of ASIC3 in muscle associated with hyperalgesia and inflammation
3) Confidence 0.72 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.80 Pain Relevance 1.45
The same acid stimuli caused no significant differences in CGRP release between ASIC3+/+ and ASIC3-/- or between B2+/+ and B2-/-, respectively.
Localization (release) of ASIC3
4) Confidence 0.66 Published 2005 Journal Cardiovasc. Res. Section Body Doc Link 15639479 Disease Relevance 0 Pain Relevance 0
The same acid stimuli caused no significant differences in CGRP release between ASIC3+/+ and ASIC3-/- or between B2+/+ and B2-/-, respectively.
Localization (release) of ASIC3
5) Confidence 0.66 Published 2005 Journal Cardiovasc. Res. Section Body Doc Link 15639479 Disease Relevance 0 Pain Relevance 0
At the cut-off time of 60 s, bout duration and approach latency showed a significant positive correlation for Asic3+/+ (R?
Localization (correlation) of Asic3
6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0 Pain Relevance 0
(ko) mice released less 5-HT than those of Asic3+/+ and Asic3?
Localization (released) of Asic3
7) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0 Pain Relevance 0.20
We localized one such channel, DRASIC, in several different specialized sensory nerve endings of skin, suggesting it might participate in mechanosensation and/or acid-evoked nociception.
Localization (localized) of DRASIC in skin associated with nociception and mechanosensation
8) Confidence 0.62 Published 2001 Journal Neuron Section Abstract Doc Link 11754838 Disease Relevance 0.09 Pain Relevance 0.11

General Comments

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