INT100135

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.76
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
neuronal 1
nodes 1
sympathetic 1
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 8 99.68 Very High Very High Very High
Calcitonin gene-related peptide 1 99.18 Very High Very High Very High
long-term potentiation 13 99.14 Very High Very High Very High
Enkephalin 2 97.58 Very High Very High Very High
Abeta 7 95.52 Very High Very High Very High
Intracerebroventricular 1 90.88 High High
ischemia 100 84.72 Quite High
Glutamate 5 84.64 Quite High
cINOD 1 84.44 Quite High
Inflammation 21 77.28 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 11 99.84 Very High Very High Very High
Targeted Disruption 6 99.74 Very High Very High Very High
Urological Neuroanatomy 6 97.80 Very High Very High Very High
Tooth Injuries 2 96.88 Very High Very High Very High
Alzheimer's Dementia 1 87.24 High High
Cv Unclassified Under Development 92 84.72 Quite High
INFLAMMATION 33 77.28 Quite High
Brain Hemorrhage 6 75.00 Quite High
Cognitive Disorder 3 75.00 Quite High
Anxiety Disorder 76 74.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss.
Negative_regulation (loss) of synaptophysin
1) Confidence 0.57 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11755008 Disease Relevance 0.61 Pain Relevance 0.54
For example, studies employing hippocampal cultures found that LTP-induced alterations in pre- (synapsin and synaptophysin) and postsynaptic (GluR1) proteins were associated with increases in the phosphorylation of the actin cytoskeleton regulators VASP and RhoA [26], and impaired following application of an actin polymerization inhibitor [24].
Negative_regulation (impaired) of synaptophysin associated with long-term potentiation
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.21 Pain Relevance 0.27
No changes occurred for neural Na(v)1.6 at axonal nodes of Ranvier, even though IR for calcitonin gene-related peptide was greatly decreased, as expected, and neural synaptophysin-IR was decreased 59% by dexamethasone.
Negative_regulation (decreased) of neural synaptophysin-IR in nodes associated with dexamethasone and calcitonin gene-related peptide
3) Confidence 0.20 Published 2009 Journal Cell Tissue Res. Section Abstract Doc Link 19763626 Disease Relevance 0.53 Pain Relevance 0.60
Segregation of met-enkephalin from vesicular acetylcholine transporter and choline acetyltransferase in sympathetic preganglionic varicosities mostly lacking synaptophysin and synaptotagmin.
Negative_regulation (lacking) of synaptophysin in sympathetic associated with enkephalin and increased venous pressure under development
4) Confidence 0.19 Published 2009 Journal Neuroscience Section Title Doc Link 19524025 Disease Relevance 0.79 Pain Relevance 0.17
Likewise, BDNF knockout mice have a reduced level of synaptophysin in hippocampal synaptosomes [71].
Negative_regulation (reduced) of synaptophysin associated with targeted disruption
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.29 Pain Relevance 0.03
Our most striking finding was that the decrease in acute microglial activation induced by 3-AB was associated with a long term down-regulation of two neuronal plasticity proteins expression, synaptophysin (marker of synaptogenesis) and GAP-43 (marker of neuritogenesis) as well as to a significant decrease in tissue BDNF production.
Negative_regulation (regulation) of synaptophysin in neuronal
6) Confidence 0.12 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779656 Disease Relevance 0.33 Pain Relevance 0.14

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