INT100137

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2005
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 15 100.00 Very High Very High Very High
Intracerebroventricular 1 99.44 Very High Very High Very High
cINOD 5 98.50 Very High Very High Very High
Inflammation 4 85.28 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 7 95.24 Very High Very High Very High
INFLAMMATION 5 85.28 High High
Disease 4 82.12 Quite High
Neurodegenerative Disease 1 80.76 Quite High
Cognitive Disorder 1 75.00 Quite High
Targeted Disruption 1 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While some NSAIDs may inhibit Abeta42 production, these observations suggest that ibuprofen reduction of Abeta pathology may not be mediated by altered Abeta42 production.
Neg (not) Spec (may) Positive_regulation (mediated) of Negative_regulation (reduction) of Abeta associated with cinod and abeta
1) Confidence 0.41 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15688088 Disease Relevance 0.60 Pain Relevance 0.61
Lipoprotein carrier-mediated, intracerebroventricular infusion of Abeta peptides induced oxidative damage, synaptophysin loss, a microglial response and widespread Abeta deposits.
Positive_regulation (induced) of Negative_regulation (loss) of Abeta associated with intracerebroventricular and abeta
2) Confidence 0.27 Published 2001 Journal Neurobiol. Aging Section Abstract Doc Link 11755008 Disease Relevance 0.65 Pain Relevance 0.55

General Comments

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