INT100139

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Context Info
Confidence 0.63
First Reported 2001
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 160
Total Number 162
Disease Relevance 97.78
Pain Relevance 14.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
liver 9
adipocytes 6
macrophage 4
intestine 3
bars 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1360 100.00 Very High Very High Very High
cytokine 244 100.00 Very High Very High Very High
agonist 2475 99.84 Very High Very High Very High
ischemia 85 99.48 Very High Very High Very High
antagonist 292 98.64 Very High Very High Very High
Inflammatory response 159 98.56 Very High Very High Very High
Osteoarthritis 73 97.36 Very High Very High Very High
cINOD 336 97.00 Very High Very High Very High
metalloproteinase 68 96.88 Very High Very High Very High
Serotonin 7 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 4129 100.00 Very High Very High Very High
Apoptosis 2518 100.00 Very High Very High Very High
INFLAMMATION 1633 100.00 Very High Very High Very High
Insulin Resistance 236 100.00 Very High Very High Very High
Targeted Disruption 162 100.00 Very High Very High Very High
Uterine Fibroids 144 99.98 Very High Very High Very High
Colon Cancer 910 99.96 Very High Very High Very High
Reperfusion Injury 12 99.86 Very High Very High Very High
Repression 147 99.82 Very High Very High Very High
Cancer 4011 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of PPAR?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PPAR
1) Confidence 0.63 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.65 Pain Relevance 0.07
Therefore, an increased expression of PPAR?
Positive_regulation (increased) of Gene_expression (expression) of PPAR
2) Confidence 0.60 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 1.21 Pain Relevance 0.29
Enhanced levels of PPAR?
Positive_regulation (Enhanced) of Gene_expression (levels) of PPAR
3) Confidence 0.57 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.42 Pain Relevance 0.21
target genes, including the adipocyte marker adiponectin, can be induced in non-adipocytes by experimental overexpression of PPAR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPAR in adipocytes associated with obesity
4) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.43 Pain Relevance 0
Overexpressing PPAR?
Positive_regulation (Overexpressing) of Gene_expression (Overexpressing) of PPAR
5) Confidence 0.55 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.98 Pain Relevance 0.17
Furthermore, these ligands upregulated EC expression of PPAR?
Positive_regulation (upregulated) of Gene_expression (expression) of PPAR
6) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.90 Pain Relevance 0.07
Many human cancer cell lines express high levels of PPAR?
Positive_regulation (levels) of Gene_expression (express) of PPAR associated with cancer
7) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.50 Pain Relevance 0.15
metabolism, increases the expression of PPAR?
Positive_regulation (increases) of Gene_expression (expression) of PPAR
8) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.19 Pain Relevance 0.12
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Positive_regulation (enhanced) of Gene_expression (expression) of PPAR associated with agonist
9) Confidence 0.50 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.61
The present paper is aimed at providing a detailed and updated overview of PPAR?
Positive_regulation (overview) of Gene_expression (overview) of PPAR
10) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.14 Pain Relevance 0.07
A recent study suggests that Adrp could serve as potential mediator of the effect of PPAR?
Positive_regulation (mediator) of Gene_expression (effect) of PPAR
11) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.22 Pain Relevance 0.07
Although the presence of a functional PPRE is often used as a criteria for designating direct PPAR?
Positive_regulation (criteria) of Gene_expression (designating) of PPAR
12) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.13 Pain Relevance 0.06
activate PPARA expression via direct binding to PPARA promoter B (?
Positive_regulation (direct) of Gene_expression (expression) of PPARA
13) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.78 Pain Relevance 0.08
PPARA promoter-reporter constructs were cotransfected with empty expression vector or vector expressing ERR?
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of PPARA
14) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.15 Pain Relevance 0
activate PPARA expression via direct binding to PPARA promoter B (?
Positive_regulation (activate) of Gene_expression (expression) of PPARA
15) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.78 Pain Relevance 0.08
It is well known that FF increases total Hcy levels by PPAR-?
Positive_regulation (increases) of Gene_expression (total) of PPAR
16) Confidence 0.49 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 0.82 Pain Relevance 0.03
First, we observed that the PPAR?
Positive_regulation (observed) of Gene_expression (observed) of PPAR
17) Confidence 0.48 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.62 Pain Relevance 0.38
However, in some cell models, both PPAR?
Positive_regulation (However) of Gene_expression (However) of PPAR
18) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 2.00 Pain Relevance 0
Several genes that are selectively upregulated by a given PPAR isotype have
Positive_regulation (upregulated) of Gene_expression (isotype) of PPAR
19) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.12 Pain Relevance 0.03
The first demonstration of PPAR?
Positive_regulation (demonstration) of Gene_expression (demonstration) of PPAR
20) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.37 Pain Relevance 0.07

General Comments

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