INT10014

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Context Info
Confidence 0.54
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.01
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Casz1) intracellular (Casz1) DNA binding (Casz1)
biological_process (Casz1) cytoplasm (Casz1)
Anatomy Link Frequency
cardiomyocytes 1
EPI 1
Casz1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 46 97.84 Very High Very High Very High
antinociception 5 95.68 Very High Very High Very High
Antinociceptive 1 80.68 Quite High
Opioid 5 71.04 Quite High
Pain 6 68.04 Quite High
Catecholamine 18 64.08 Quite High
Nicotine 4 63.24 Quite High
analgesia 2 61.92 Quite High
antagonist 6 60.96 Quite High
narcan 2 58.32 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 46 97.84 Very High Very High Very High
Contracture 18 97.44 Very High Very High Very High
Cadaver 1 94.12 High High
Hypothermia 4 93.44 High High
Recurrence 12 85.68 High High
Hernia 47 83.80 Quite High
Injury 12 83.36 Quite High
Hypertension 8 81.76 Quite High
Myocardial Infarction 22 74.64 Quite High
Abdominal Aortic Aneurysm 1 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the CST synthesis inhibitor, aminoglutethemide (AG: 2 x 25 mg/kg, i.p.), reduced plasma CST levels while not significantly affecting EPI.
Gene_expression (levels) of CST in EPI
1) Confidence 0.54 Published 1992 Journal Pain Section Abstract Doc Link 1454390 Disease Relevance 0.22 Pain Relevance 0.92
Several in vivo studies were performed after the introduction of the CST.
Gene_expression (introduction) of CST
2) Confidence 0.51 Published 2010 Journal Hernia Section Body Doc Link PMC2908454 Disease Relevance 0.86 Pain Relevance 0
Furthermore, CST was found to be protective in a model of isolated cardiomyocytes exposed to simulated ischemia, increasing cell viability rate of about 65%.
Gene_expression (protective) of CST in cardiomyocytes associated with ischemia
3) Confidence 0.49 Published 2010 Journal Cell Mol Neurobiol Section Body Doc Link PMC3008938 Disease Relevance 0.42 Pain Relevance 0.14
In Group 3 (CST-Post group, n = 7) in lieu of PostC, CST (75 nM) was infused for 20 min at the beginning of reperfusion (Fig. 1a).
Gene_expression (group) of CST-Post
4) Confidence 0.43 Published 2010 Journal Cell Mol Neurobiol Section Body Doc Link PMC3008938 Disease Relevance 0.50 Pain Relevance 0.22

General Comments

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