INT100142

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 3
Disease Relevance 1.71
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
platelet 2
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 4 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
cINOD 8 83.52 Quite High
aspirin 4 82.84 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 8 100.00 Very High Very High Very High
Cancer 8 94.36 High High
Apoptosis 2 93.00 High High
Metastasis 2 90.44 High High
INFLAMMATION 1 41.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, the S(+)-isomer of ibuprofen was 32-, 41-, and 96-fold more potent than the R(-)-isomer for the inhibition of PGHS-1 activity, human platelet aggregation, and serotonin secretion, respectively.
Negative_regulation (inhibition) of Localization (secretion) of PGHS-1 in platelet associated with serotonin
1) Confidence 0.35 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11755111 Disease Relevance 0 Pain Relevance 0.24
Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?
Negative_regulation (lost) of Localization (cause) of Cyclooxygenase associated with colon cancer and cox2
2) Confidence 0.11 Published 2009 Journal Expert Opin. Ther. Targets Section Title Doc Link 19236238 Disease Relevance 0.86 Pain Relevance 0.34
Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?
Negative_regulation (chemoprevention) of Localization (cause) of Cyclooxygenase associated with colon cancer and cox2
3) Confidence 0.11 Published 2009 Journal Expert Opin. Ther. Targets Section Title Doc Link 19236238 Disease Relevance 0.86 Pain Relevance 0.34

General Comments

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