INT100144

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 12.71
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
endothelial cells 2
muscle 2
reticulum 2
PPARA (Homo sapiens)
PPARA - V290M (1)
Pain Link Frequency Relevance Heat
Inflammatory mediators 11 100.00 Very High Very High Very High
agonist 102 99.84 Very High Very High Very High
Inflammation 63 99.58 Very High Very High Very High
cINOD 35 99.18 Very High Very High Very High
Osteoarthritis 130 97.00 Very High Very High Very High
COX-2 inhibitor 5 95.72 Very High Very High Very High
Bile 10 87.68 High High
Angina 4 84.68 Quite High
antagonist 26 83.32 Quite High
Serotonin 2 83.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 89 100.00 Very High Very High Very High
Apoptosis 203 98.96 Very High Very High Very High
Stress 25 98.76 Very High Very High Very High
Cancer 201 98.64 Very High Very High Very High
Colorectal Cancer 46 97.56 Very High Very High Very High
Osteoarthritis 132 97.00 Very High Very High Very High
Diabetes Mellitus 137 96.88 Very High Very High Very High
Familial Adenomatous Polyposis 1 96.16 Very High Very High Very High
Insulin Resistance 16 95.92 Very High Very High Very High
Colon Cancer 41 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar decreased activation of variant PPARA ?
Negative_regulation (decreased) of Positive_regulation (activation) of PPARA
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
These results demonstrate that the mechanisms of action of NSAIDs on these cell systems are different, and we propose that the pharmacological effects of NSAIDs may be related to both their profile of inhibition of PGHS enzymes and the activation of PPARalpha and/or PPARgamma isoforms.
Negative_regulation (inhibition) of Positive_regulation (activation) of PPARalpha associated with cinod
2) Confidence 0.39 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11755111 Disease Relevance 0 Pain Relevance 0.26
Taken together, the human, mouse, and cell culture studies represent a comprehensive evaluation of PPAR?
Negative_regulation (comprehensive) of Positive_regulation (evaluation) of PPAR
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.75 Pain Relevance 0.12
In addition, inhibition of Cox-2 and activation of PPAR?
Negative_regulation (inhibition) of Positive_regulation (activation) of PPAR
4) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.07 Pain Relevance 0.46
Selective inhibitors of ERK, p38 MAPK, and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin-induced cytotoxicity and reduced increased caspase activity.
Negative_regulation (suppressed) of Positive_regulation (induction) of PPAR
5) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.83 Pain Relevance 0.06
In addition, the concomitant induction of peroxisome proliferator-activated receptor (PPAR), especially PPAR-beta, was apparent in treated cells.
Negative_regulation (apparent) of Positive_regulation (induction) of PPAR
6) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.08 Pain Relevance 0.20
In addition, the concomitant induction of peroxisome proliferator-activated receptor (PPAR), especially PPAR-beta, was apparent in treated cells.
Negative_regulation (apparent) of Positive_regulation (induction) of peroxisome proliferator-activated receptor
7) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.08 Pain Relevance 0.20
In addition, the concomitant induction of peroxisome proliferator-activated receptor (PPAR), especially PPAR-beta, was apparent in treated cells.
Negative_regulation (apparent) of Positive_regulation (induction) of PPAR
8) Confidence 0.34 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.08 Pain Relevance 0.20
activation or inhibition of PPAR?
Negative_regulation (inhibition) of Positive_regulation (activation) of PPAR
9) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.52 Pain Relevance 0.23
in muscle have also been published, showing that muscle specific PPAR?
Negative_regulation (published) of Positive_regulation (muscle) of PPAR in muscle
10) Confidence 0.31 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.55 Pain Relevance 0.03
Other studies support a downregulation of this endoplasmic reticulum enzyme upon induction with PPAR?
Negative_regulation (downregulation) of Positive_regulation (induction) of PPAR in reticulum
11) Confidence 0.30 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.47 Pain Relevance 0.23
1 promoter, we could not exclude a specific effect of IL-1 on the stability of PPAR?
Negative_regulation (effect) of Positive_regulation (stability) of PPAR
12) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.39 Pain Relevance 0.19
We therefore cannot exclude the possibility of a role for these inflammatory mediators in PPAR?
Spec (possibility) Negative_regulation (possibility) of Positive_regulation (role) of PPAR associated with inflammatory mediators
13) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 1.25 Pain Relevance 0.38
Several studies have described increased or decreased levels of PPAR?
Negative_regulation (decreased) of Positive_regulation (increased) of PPAR
14) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.62 Pain Relevance 0
restored the SSAT promoter activity, and an activated PPAR?
Negative_regulation (restored) of Positive_regulation (activated) of PPAR
15) Confidence 0.18 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.48 Pain Relevance 0
Increasing amounts of V290M PPAR?
Negative_regulation (amounts) of Positive_regulation (Increasing) of PPAR (V290M)
16) Confidence 0.11 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1368963 Disease Relevance 0.12 Pain Relevance 0
endothelial cells and inhibited angiogenesis, also through activation of PPAR?
Negative_regulation (inhibited) of Positive_regulation (activation) of PPAR in endothelial cells
17) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.88 Pain Relevance 0.04
The latter have anti-inflammatory and neuroprotective effect, partly because they activate nuclear peroxisome proliferator-activated receptors (PPAR) and partly because they inhibit GSK-3?
Negative_regulation (effect) of Positive_regulation (activate) of PPAR associated with inflammation
18) Confidence 0.06 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.55 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox