INT100154

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.48
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PITX2) transcription factor binding (PITX2)
Anatomy Link Frequency
skin 1
N18 1
PITX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 99.84 Very High Very High Very High
Opioid 5 83.84 Quite High
Cannabinoid 1 83.12 Quite High
Dopamine 2 81.68 Quite High
drug abuse 1 81.12 Quite High
opioid receptor 4 80.56 Quite High
Cannabinoid receptor 9 79.92 Quite High
agonist 5 79.28 Quite High
Kappa opioid receptor 3 75.00 Quite High
Somatostatin 3 73.16 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 29 90.60 High High
Disease 1 71.12 Quite High
Neuroblastoma 3 56.12 Quite High
Cancer 18 54.20 Quite High
Bordatella Infection 1 25.00 Low Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pituitary Cancer 1 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Solid Tumor 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulators of G-protein signaling (RGS) proteins have been shown to modulate the function of some heterotrimeric G-proteins by stimulating the GTPase activity of G-protein alpha subunits.
Regulation (regulators) of RGS
1) Confidence 0.60 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11755131 Disease Relevance 0 Pain Relevance 0.43
Regulator of G protein-signaling (RGS) proteins are a family of more than 30 intracellular proteins that negatively modulate intracellular signaling of receptors in the G protein-coupled receptor family.
Regulation (Regulator) of RGS
2) Confidence 0.44 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20201861 Disease Relevance 0.07 Pain Relevance 0.20
In this article, we discuss RGS proteins, their regulation by morphine and stimulants, and how altered levels of these proteins affect cell signaling to contribute to the pharmacology and behavioral consequence of abused drugs.
Regulation (regulation) of RGS associated with morphine
3) Confidence 0.26 Published 2005 Journal Mol. Interv. Section Abstract Doc Link 15734717 Disease Relevance 0 Pain Relevance 0.22
N18 cells' GPCRs are also presumably tightly regulated based on the assortment of GRK, RGS and beta-arrestin mRNAs detected (figures 5 and 6).
Regulation (regulated) of RGS in N18
4) Confidence 0.02 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.06 Pain Relevance 0.30
The SNPs rs689465, rs689466, rs20417 and rs5275 were further studied: Their genotypic distributions followed Hardy-Weinberg equilibrium and the MAFs were not affected by gender or skin color.
Neg (not) Regulation (affected) of SNPs rs689465 in skin
5) Confidence 0.00 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2992523 Disease Relevance 0.35 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox