INT10016

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1988
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 81
Total Number 83
Disease Relevance 56.68
Pain Relevance 13.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cell 22
lymphocytes 21
NK cells 3
granulocytes 2
B cells 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 260 100.00 Very High Very High Very High
Morphine 8 99.98 Very High Very High Very High
spinal inflammation 11 99.68 Very High Very High Very High
fluoxetine 3 99.40 Very High Very High Very High
methotrexate 29 99.08 Very High Very High Very High
antidepressant 5 99.06 Very High Very High Very High
Inflammation 223 97.84 Very High Very High Very High
depression 34 97.36 Very High Very High Very High
Pain 102 96.76 Very High Very High Very High
opiate 3 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphopenia 57 99.88 Very High Very High Very High
Infection 835 99.76 Very High Very High Very High
Low Back Pain 14 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 567 99.52 Very High Very High Very High
Thrombocytopenia 4 99.44 Very High Very High Very High
Cold Sores 609 99.08 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 296 99.06 Very High Very High Very High
Apoptosis 189 99.04 Very High Very High Very High
Hepatitis C Virus Infection 15 98.92 Very High Very High Very High
Herpes Zoster 13 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No statistically significant changes were seen in absolute CD4 or CD8 cell counts, although a modest decrease (16%) in CD8 counts occurred.
Negative_regulation (decrease) of CD8
1) Confidence 0.42 Published 1991 Journal Clin Invest Med Section Abstract Doc Link 1829401 Disease Relevance 0.62 Pain Relevance 0.31
Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers.
Negative_regulation (Priming) of CD8 in T cell associated with hepatitis c virus infection and cytokine
2) Confidence 0.42 Published 2009 Journal Human vaccines Section Title Doc Link 19246990 Disease Relevance 0.90 Pain Relevance 0.05
In our patient a decrease of T-helper cells and a significant lowered CD4/CD8 ratio could be detected.
Negative_regulation (decrease) of CD8 in T-helper cells
3) Confidence 0.42 Published 1995 Journal Neurol. Res. Section Abstract Doc Link 7477751 Disease Relevance 0.76 Pain Relevance 0.09
We treated the patient by lymphocytapheresis (LCP), which resulted in an improvement of his symptoms, a reduction in the CD4 lymphocyte population, a reduction of the CD4/CD8 ratio, and a reduced thickening of the dura mater that lasted for more than 14 months.
Negative_regulation (reduction) of CD8 in lymphocyte
4) Confidence 0.42 Published 2000 Journal Ther Apher Section Abstract Doc Link 10975480 Disease Relevance 0.86 Pain Relevance 0.26
Laboratory tests revealed lymphocytopenia with low CD4+ T cell counts (<100/microl) and a decreased CD4/CD8 ratio.
Negative_regulation (decreased) of CD8 in T cell associated with lymphopenia
5) Confidence 0.42 Published 2003 Journal Respiration Section Abstract Doc Link 12584405 Disease Relevance 2.26 Pain Relevance 0.09
Bronchoalveolar lavage examination showed an increase in the percentage of lymphocytes and a decrease of CD4/CD8 ratio.
Negative_regulation (decrease) of CD8 in lymphocytes
6) Confidence 0.42 Published 1993 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8121097 Disease Relevance 0.56 Pain Relevance 0.44
High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes.
Negative_regulation (reduction) of Leu 2 in lymphocytes associated with methotrexate
7) Confidence 0.42 Published 1988 Journal J. Rheumatol. Section Abstract Doc Link 3258915 Disease Relevance 0.34 Pain Relevance 0.30
Biopsy of the mass demonstrated a high-grade B-cell non-Hodgkin's lymphoma, and the patient was classified in group IV-D of the human immunodeficiency virus infection because he had HIV serum antibodies and a reduced CD4/CD8 lymphocyte ratio.
Negative_regulation (reduced) of CD8 in lymphocyte associated with lymphatic system cancer and acquired immune deficiency syndrome or hiv infection
8) Confidence 0.42 Published 1991 Journal Med Clin (Barc) Section Abstract Doc Link 1895785 Disease Relevance 1.30 Pain Relevance 0.09
Morphine inhibits CD8+ T cell-mediated, noncytolytic, anti-HIV activity in latently infected immune cells.
Negative_regulation (inhibits) of CD8 in immune cells associated with acquired immune deficiency syndrome or hiv infection and morphine
9) Confidence 0.42 Published 2005 Journal J. Leukoc. Biol. Section Title Doc Link 16000393 Disease Relevance 0.90 Pain Relevance 0.73
Operation trauma on the other hand causes depression of the auxiliary T lymphocyte population (CD4) and the stimulation of the cytotoxic T cell subpopulation (CD8) with a pathological reduction of the quotient factor of these lymphocyte sub-populations CD4/CD8.
Negative_regulation (reduction) of CD8 in cytotoxic T cell associated with depression and injury
10) Confidence 0.41 Published 1994 Journal Folia Med Cracov Section Abstract Doc Link 8586330 Disease Relevance 0.27 Pain Relevance 0.64
Common laboratory features include lymphopenia with depletion of CD4 and CD8 lymphocytes, thrombocytopenia, prolonged activated partial thromboplastin time, elevated D-Dimer, elevated alanine transminases, lactate dehydrogenase and creatinine kinase.
Spec (partial) Negative_regulation (depletion) of CD8 in lymphocytes associated with lymphopenia and thrombocytopenia
11) Confidence 0.41 Published 2003 Journal Respirology Section Abstract Doc Link 15018129 Disease Relevance 1.83 Pain Relevance 0.09
Peripheric blood flow-cytometric analysis revealed a significant decrease in absolute CD4+ T lymphocytes, and in CD8+28+ T lymphocytes in addition a significant increase in natural killer cell ratio.
Negative_regulation (decrease) of CD8 in natural killer cell
12) Confidence 0.41 Published 2008 Journal Mikrobiyol Bul Section Abstract Doc Link 18822899 Disease Relevance 1.60 Pain Relevance 0.12
A lymphocyte stimulation test (DLST) with clopidogrel was positive, and bronchoalveolar lavage fluid showed an increase in lymphocytes and a decrease in the CD4+/CD8+ ratio.
Negative_regulation (decrease) of CD8 in lymphocyte
13) Confidence 0.41 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20560445 Disease Relevance 0.32 Pain Relevance 0.08
Lymphocyte subset analyses on blood from 11 subjects showed a decreasing total CD8 + lymphocyte concentration for the TT group.
Negative_regulation (decreasing) of CD8 in lymphocyte
14) Confidence 0.40 Published 1998 Journal J Adv Nurs Section Abstract Doc Link 9687125 Disease Relevance 1.20 Pain Relevance 0.71
Using in vivo MR spectroscopy and post-mortem IHC, our group has previously shown that CD8 depletion without SIV infection does not change brain metabolism or provoke neuronal or glial degradation [20].
Negative_regulation (depletion) of CD8 in neuronal associated with infection
15) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.51 Pain Relevance 0
The uninfected CD8-depleted cohort was chosen to detect the effect of minocycline on SIV infection and not on CD8 depletion.
Neg (not) Negative_regulation (depletion) of CD8 associated with infection
16) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.56 Pain Relevance 0
CD8+ T lymphocyte depletion was monitored by flow cytometry prior to infection and CD8 depletion and weekly thereafter.
Negative_regulation (depletion) of CD8 in T lymphocyte associated with infection
17) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.10 Pain Relevance 0
All four untreated and four of the seven minocycline-treated animals had persistent depletion of CD8+ lymphocytes.
Negative_regulation (depletion) of CD8 in lymphocytes
18) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.35 Pain Relevance 0.04
Eleven rhesus macaques were infected with SIV, depleted of CD8+ lymphocytes, and studied until eight weeks post inoculation (wpi).
Negative_regulation (depleted) of CD8 in lymphocytes
19) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2866543 Disease Relevance 0.42 Pain Relevance 0
As seen in Figure 2, all patients possessed CD8+ T cell reactivity to the pool of dominant WNV epitopes.
Negative_regulation (possessed) of CD8 in T cell
20) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox