INT100167

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.31
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Utrn) nucleus (Utrn) cytoplasm (Utrn)
Anatomy Link Frequency
muscle 4
muscle cells 2
skeletal muscle 2
myotubes 2
Utrn (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 2 98.68 Very High Very High Very High
Kinase C 4 78.96 Quite High
fibrosis 92 74.76 Quite High
palliative 10 65.36 Quite High
metalloproteinase 4 59.80 Quite High
Inflammation 32 25.60 Quite Low
Neurotransmitter 22 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 96.28 Very High Very High Very High
Muscular Dystrophy 95 95.12 Very High Very High Very High
Injury 4 82.00 Quite High
Necrosis 9 78.92 Quite High
Fibrosis 112 74.76 Quite High
Apoptosis 4 48.96 Quite Low
Stress 1 47.04 Quite Low
Body Weight 92 32.12 Quite Low
INFLAMMATION 40 25.60 Quite Low
Congenital Anomalies 12 16.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have demonstrated an overexpression of utrophin, visualised by immunofluorescence and quantified by Western blotting, in normal myotubes and in mdx (the animal model of DMD) myotubes, as in normal (C57) and mdx mice, both treated with nitric oxide (NO) donor or L-arginine, the NOS substrate.
Positive_regulation (overexpression) of Gene_expression (overexpression) of utrophin in myotubes associated with muscular dystrophy
1) Confidence 0.67 Published 2002 Journal J. Physiol. Paris Section Abstract Doc Link 11755782 Disease Relevance 0.30 Pain Relevance 0.11
However, since increased NO production results in enhanced utrophin expression [80] and treatment of mdx mice with a nNOS substrate, l-arginine, also increases utrophin levels and its membrane localization [81], clinical manipulation of nNOS levels in the muscle is considered a potential starting point for therapeutic intervention [82].
Positive_regulation (enhanced) of Gene_expression (expression) of utrophin in muscle
2) Confidence 0.45 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.19 Pain Relevance 0.14
Also, a translational regulatory mechanism involving increased IRES activation has recently been shown to mediate increased expression of utrophin A in muscle cells treated with glucocorticoids [29].
Positive_regulation (increased) of Gene_expression (expression) of utrophin in muscle cells
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.11 Pain Relevance 0
In contrast, L-arginine treatment has previously been shown to induce utrophin expression in mdx mouse muscle [25], [27].
Positive_regulation (induce) of Gene_expression (expression) of utrophin in muscle
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.36 Pain Relevance 0.13
Effect on utrophin expression
Positive_regulation (on) of Gene_expression (expression) of utrophin
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.18 Pain Relevance 0.09
Glucocorticoid treatment of the mdx mouse has previously been shown to stimulate utrophin A expression in skeletal muscle fibers [28].
Positive_regulation (stimulate) of Gene_expression (expression) of utrophin in skeletal muscle
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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