INT10017

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.01
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (REL) DNA binding (REL)
Anatomy Link Frequency
T cells 1
REL (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 12 97.84 Very High Very High Very High
Biofeedback 4 90.00 High High
Inflammation 13 71.96 Quite High
aspirin 3 30.12 Quite Low
Dynorphin 6 27.20 Quite Low
Enkephalin 3 25.00 Low Low
dexamethasone 1 17.32 Low Low
cytokine 30 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 1 97.84 Very High Very High Very High
Headache 4 95.12 Very High Very High Very High
Cancer 41 94.64 High High
Injury 6 92.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 282 89.44 High High
Tension-type Headache 1 81.76 Quite High
Apoptosis 25 75.32 Quite High
Headache Disorders 1 75.00 Quite High
INFLAMMATION 17 71.96 Quite High
Prostate Cancer 1 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B are dimeric complexes, composed of various combinations of members of the Rel/NF-?
Gene_expression (/) of Rel
1) Confidence 0.65 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.26 Pain Relevance 0.04
Three main kappa B-specific factors, presumably a p50 homodimer, NF-kappa B which is a p50/p65 heterodimer and a p65/c-Rel heterodimer were identified using an electromobility shift assay (EMSA), immunoabsorption and UV cross-linking experiments.
Gene_expression (identified) of c-Rel
2) Confidence 0.47 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
Three main kappa B-specific factors, presumably a p50 homodimer, NF-kappa B which is a p50/p65 heterodimer and a p65/c-Rel heterodimer were identified using an electromobility shift assay (EMSA), immunoabsorption and UV cross-linking experiments.
Gene_expression (presumably) of c-Rel
3) Confidence 0.47 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
Peptides, 34 (1991) 181-188] and we report here that several DNA-binding factors of the NF-kappa B/c-Rel-family are present in the same cells.
Gene_expression (present) of c-Rel
4) Confidence 0.42 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7968369 Disease Relevance 0.09 Pain Relevance 0
The results indicate that REL + TEMP produced no additional improvements over REL following the 8-week treatment program, or at 6-month, or 12-month follow-up.
Neg (no) Gene_expression (produced) of REL
5) Confidence 0.18 Published 1992 Journal Pain Section Abstract Doc Link 1454404 Disease Relevance 0.52 Pain Relevance 0.75
B2 p52, c-Rel, and RelB were expressed.


Gene_expression (expressed) of c-Rel
6) Confidence 0.11 Published 2001 Journal BMC Mol Biol Section Body Doc Link PMC48145 Disease Relevance 0.09 Pain Relevance 0
B in T cells is predominantly composed of p65 or c-Rel bound to p50 or p52, whereas in MDMs, Rel B replaces p65 [97-100].
Gene_expression (composed) of c-Rel in T cells
7) Confidence 0.09 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.40 Pain Relevance 0
B1/p50, c-Rel, RelB, and NF-?
Gene_expression (/) of c-Rel
8) Confidence 0.09 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.47 Pain Relevance 0
V(t)rel, AM ?
Gene_expression (rel) of rel
9) Confidence 0.01 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0

General Comments

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