INT100188

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.96
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
sensory neurons 2
neuronal 2
ganglia 2
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 1 99.54 Very High Very High Very High
spastic colon 3 97.70 Very High Very High Very High
Inflammation 32 97.50 Very High Very High Very High
nud 5 97.08 Very High Very High Very High
Visceral pain 6 91.92 High High
adenocard 4 91.76 High High
Neuropathic pain 72 91.52 High High
Action potential 3 91.36 High High
bradykinin 8 90.08 High High
inferior alveolar nerve 2 89.20 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 5 99.98 Very High Very High Very High
Nervous System Injury 86 99.76 Very High Very High Very High
Injury 16 99.30 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 97.70 Very High Very High Very High
INFLAMMATION 31 97.50 Very High Very High Very High
Dyspepsia 5 97.08 Very High Very High Very High
Heart Injuries 1 92.92 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 91.92 High High
Neuropathic Pain 154 91.52 High High
Heart Rate Under Development 2 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, inflammation caused a twofold to threefold increase in both ATP-activated currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P2X3 receptors.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X3 associated with addiction and inflammation
1) Confidence 0.49 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756492 Disease Relevance 0.89 Pain Relevance 0.69
The expression of P2X3 receptors on the cell membrane is significantly enhanced while the total expression of P2X3 receptors remained unchanged.
Positive_regulation (enhanced) of Gene_expression (expression) of P2X3
2) Confidence 0.47 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 0.90 Pain Relevance 0.39
The myocardial ischemic injury increased the expression of P2X3 immunoreactivity and mRNA in nodose ganglia.
Positive_regulation (increased) of Gene_expression (expression) of P2X3 in ganglia associated with myocardial infarction
3) Confidence 0.41 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.14 Pain Relevance 0.15
Ramer et al. have shown that GDNF treatment increases P2X3 expression.
Positive_regulation (increases) of Gene_expression (expression) of P2X3
4) Confidence 0.34 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.68 Pain Relevance 0.52
Chronic functional visceral hyperalgesia induced in a rat model for IBS, induced by colonic injection of 0.5% acetic acid, is associated with potentiation of ATP-evoked responses and an enhanced expression of P2X3 receptors in colon-specific sensory neurons [71].
Positive_regulation (enhanced) of Gene_expression (expression) of P2X3 in sensory neurons associated with spastic colon and nud
5) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2789721 Disease Relevance 0.94 Pain Relevance 0.59
The discrepancy in the change of P2X3 expression might be due to the type of nerve injury model, since a recent study using activating transcription factor 3, a neuronal injury maker, has shown that there is an increase in the expression of P2X3 in DRG neurons whose axons had been spared following partial nerve injury [33].
Positive_regulation (increase) of Gene_expression (expression) of P2X3 in neuronal associated with nervous system injury and injury
6) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.01 Pain Relevance 0.52
HEK293 cells were transiently cotransfected with EGFP and wild-type or mutant rat P2X3 in pcDNA3 using PolyFect Transfection Reagent (Qiagen) according to the manufacturer's instructions.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of P2X3
7) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.14 Pain Relevance 0.10
A sample of mock-transfected cells was simultaneously probed with the P2X2 and P2X3 subunit-specific polyclonal antibodies
Positive_regulation (simultaneously) of Gene_expression (probed) of P2X3
8) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.31

General Comments

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