INT10019

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Context Info
Confidence 0.36
First Reported 1987
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 57
Total Number 60
Disease Relevance 31.49
Pain Relevance 10.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 34
lymphocytes 6
Cytotoxic T lymphocytes 2
B cells 2
NK cells 2
CD8A (Homo sapiens)
CD8A - T394A (1)
Pain Link Frequency Relevance Heat
Arthritis 268 99.84 Very High Very High Very High
Inflammation 247 99.56 Very High Very High Very High
nud 30 99.28 Very High Very High Very High
cytokine 419 99.04 Very High Very High Very High
methadone 18 98.40 Very High Very High Very High
spinal inflammation 115 98.10 Very High Very High Very High
Acupuncture 280 97.84 Very High Very High Very High
agonist 22 97.00 Very High Very High Very High
abdominal pain 5 96.80 Very High Very High Very High
rheumatoid arthritis 406 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 160 100.00 Very High Very High Very High
Lymphopenia 54 100.00 Very High Very High Very High
Lymphatic System Cancer 26 100.00 Very High Very High Very High
Rheumatoid Arthritis 513 99.84 Very High Very High Very High
Enteropathy 2 99.74 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 176 99.64 Very High Very High Very High
INFLAMMATION 254 99.56 Very High Very High Very High
Cancer 633 99.48 Very High Very High Very High
Alagille Syndrome 25 99.44 Very High Very High Very High
Rickettsiaceae Infection 5 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human leukocyte antigen (HLA) typing revealed A24 positivity, suggesting this molecule was interacting with CD8(+) T lymphocytes.
CD8 Binding (interacting) of in T lymphocytes
1) Confidence 0.36 Published 2007 Journal Mod Rheumatol Section Abstract Doc Link 17278028 Disease Relevance 0.88 Pain Relevance 0.28
The naturally occurring polymorphism Asp116-->His116, differentiating the ankylosing spondylitis-associated HLA-B*2705 from the non-associated HLA-B*2709 subtype, influences peptide-specific CD8 T cell recognition.
CD8 Binding (recognition) of in T cell associated with spinal inflammation
2) Confidence 0.36 Published 1998 Journal Eur. J. Immunol. Section Title Doc Link 9710228 Disease Relevance 0.47 Pain Relevance 0.42
It has been suggested, therefore, that the amount of CD8+ CTLs in a peripheral blood sample can be estimated by determining the percentage of CD8+ CD28- T cells.
CD8 Binding (percentage) of in blood
3) Confidence 0.35 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.63 Pain Relevance 0.33
Cells were then stained for their surface antigens CD28 and CD8 and, after permeabilization, with FITC-conjugated anti-perforin, anti-IFN-?
CD8 Binding (stained) of
4) Confidence 0.35 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.34 Pain Relevance 0.18
In the blood, virus-specific tetramer-binding CD3+ CD8+ T-cells appeared earlier in macaque 817, exposed to SIVmac251 by the intrarectal route, than in 819 for all the 3 antigens studied (Figs. 1B and 1D).
CD8 Spec (appeared) Binding (binding) of in T-cells
5) Confidence 0.32 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.16 Pain Relevance 0
In the biopsied samples from the anastomosis site, there was diffuse proliferation of large lymphoid cells, which were immunohistochemically positive for CD3 and CD4, but negative for CD8 and CD20.
CD8 Binding (negative) of
6) Confidence 0.32 Published 2010 Journal Pathol. Res. Pract. Section Abstract Doc Link 19836149 Disease Relevance 0.49 Pain Relevance 0.09
Cytotoxic T lymphocytes were determined by UCHT1/B9.11 indexed for CD3/CD8.
CD8 Spec (determined) Binding (indexed) of in Cytotoxic T lymphocytes
7) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2988071 Disease Relevance 0.05 Pain Relevance 0
Graded antigen stability occurred: CD3 most stable, CD8 least, and CD4 intermediate.
CD8 Binding (intermediate) of
8) Confidence 0.28 Published 1987 Journal J. Histochem. Cytochem. Section Abstract Doc Link 3309048 Disease Relevance 0 Pain Relevance 0.06
The CD2+, CD4+ and CD8+ levels, which are closely associated with activity of T cells, were statistically unchanged except on day 8 after acupuncture (P < 0.05).
CD8 Binding (associated) of in T cells associated with acupuncture
9) Confidence 0.25 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.24
Cell counts of CD2+, CD4+, CD8+, CD11b+, CD16+, CD19+ and CD56+ were evaluated for variations in T cells, B cells, macrophages and NK cells after acupuncture treatment.
CD8 Binding (counts) of in T cells associated with acupuncture
10) Confidence 0.25 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.13
PBMCs were then stimulated by the HBsAg peptide pool for 18 hours in the presence of brefeldin A and stained with fluorochrome-conjugated CD3, CD4, CD8, IL-2, INF-?
CD8 Binding (fluorochrome) of
11) Confidence 0.22 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.22 Pain Relevance 0.16
Positive gating for lymphocytes based on forward and side scatter was followed by CD3+CD4+ and CD3+CD8+ gating, and specific populations were further defined by using antibodies specific for CD95.
CD8 Binding (gating) of in lymphocytes
12) Confidence 0.22 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.09 Pain Relevance 0.13
After exclusion of CD14+ monocytes, the binding of pentamers on CD3+CD8+ cells was determined.


CD8 Binding (binding) of in monocytes
13) Confidence 0.21 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.06 Pain Relevance 0.07
We found that T CD4 and CD8 lymphocytes underwent massive apoptosis in ZEBOV fatalities, largely through Fas/FasL interaction, whereas the level of lymphocyte apoptosis seen in the survivors was close to that found in the healthy controls.
CD8 Binding (interaction) of in lymphocyte associated with apoptosis
14) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.90 Pain Relevance 0.06
With the MHC-Dextramer assay, which can detect the T-cell receptor capable of binding specifically to the gp100-in4 peptide presented on a particular MHC molecule, an increase in frequency of T-cells with the gp-100-specific T-cell receptor was observed in all patients after the initiation of vaccination.
T-cell receptor Binding (binding) of in T-cells
15) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.34 Pain Relevance 0
These compounds are immunomodulators, modifying immune responses to extracellular stimuli such as mitogens, antigens, and antibodies that cross-link the T-cell receptor.
T-cell receptor Binding (link) of in T-cell
16) Confidence 0.20 Published 2006 Journal Brain Behav. Immun. Section Abstract Doc Link 16364815 Disease Relevance 0 Pain Relevance 0.76
CD8+ T cell associated TRAIL and its receptor expression profile in RA
CD8 Binding (associated) of in T cell associated with arthritis
17) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.62 Pain Relevance 0.27
CD8+ T cell associated TRAIL and its receptor expression profile in RA
CD8 Binding (profile) of in T cell associated with arthritis
18) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.62 Pain Relevance 0.28
In general, these compounds act as immunomodulators that modify the immune response to mitogens, antigens and antibodies that cross-link the T-cell receptor.
T-cell receptor Binding (cross-link) of in T-cell
19) Confidence 0.18 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 12617568 Disease Relevance 0 Pain Relevance 0.67
CD8+ T cell responses to mycobacteria have been shown to be induced through vaccination with BCG in older subjects, or following latent infection or active disease [30], [35], [36], [37].
CD8 Binding (vaccination) of in T cell associated with disease and infection
20) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2694271 Disease Relevance 0.53 Pain Relevance 0

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