INT100190

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.80
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
spinal 2
colon 2
neurons 2
amygdala 2
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 10 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
midbrain 5 99.68 Very High Very High Very High
fluoxetine 7 98.52 Very High Very High Very High
amygdala 2 98.28 Very High Very High Very High
central pain 2 97.28 Very High Very High Very High
nud 4 95.60 Very High Very High Very High
Spinal cord 1 95.28 Very High Very High Very High
Pain threshold 2 93.96 High High
withdrawal 1 93.04 High High
Disease Link Frequency Relevance Heat
Pain 7 96.96 Very High Very High Very High
Dyspepsia 4 95.60 Very High Very High Very High
Frailty 5 95.28 Very High Very High Very High
Syndrome 1 92.72 High High
Stress 8 88.80 High High
Neuropathic Pain 2 88.32 High High
Gliosis 5 88.00 High High
Hyperalgesia 3 87.76 High High
Functional Bowel Disorder 1 79.04 Quite High
Urological Neuroanatomy 2 47.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat.
Regulation (Changes) of Gene_expression (expression) of serotonin transporter in spinal associated with pain, central pain and serotonin
1) Confidence 0.39 Published 2002 Journal Exp. Neurol. Section Title Doc Link 12061865 Disease Relevance 0.81 Pain Relevance 1.01
In addition, the effect of EA on 5-HT(4a) receptor and serotonin transporter (SERT) expression in the colon mucosa was analyzed semi-quantitatively through immunohistochemistry and 5-HT concentration in the colon tissue was observed through spectro-photo-fluorimeter detection, respectively.
Regulation (effect) of Gene_expression (expression) of serotonin transporter in colon associated with serotonin
2) Confidence 0.36 Published 2006 Journal Brain Res. Section Abstract Doc Link 16650387 Disease Relevance 0.90 Pain Relevance 0.69
Fluoxetine treatment for 4 and 8, but not for 2 weeks, abolished these swim-induced changes in TPH2 and 5-HTT mRNAs levels in the midbrain and 5-HIAA content in the amygdala.
Regulation (changes) of Gene_expression (levels) of 5-HTT in amygdala associated with midbrain, amygdala and fluoxetine
3) Confidence 0.22 Published 2007 Journal Neuroscience Section Abstract Doc Link 17950541 Disease Relevance 0 Pain Relevance 1.12
Psychostimulants differentially regulate serotonin transporter expression in thalamocortical neurons.
Regulation (regulate) of Gene_expression (expression) of serotonin transporter in neurons associated with serotonin
4) Confidence 0.14 Published 2002 Journal J. Neurosci. Section Title Doc Link 11756522 Disease Relevance 0 Pain Relevance 0.23
0.040) without affecting 5-HTT protein expression (Fig. 5A and B).


Neg (without) Regulation (affecting) of Gene_expression (expression) of 5-HTT protein
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.09 Pain Relevance 0.07

General Comments

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