INT1002

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2005
Negated 5
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0.63
Pain Relevance 5.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ggh) extracellular space (Ggh) extracellular region (Ggh)
lysosome (Ggh)
Anatomy Link Frequency
somatotrope 2
pituitary 2
anterior pituitary 2
Ggh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 35 100.00 Very High Very High Very High
Clonidine 22 99.60 Very High Very High Very High
Analgesic 8 99.52 Very High Very High Very High
Morphine 7 99.52 Very High Very High Very High
tolerance 2 99.30 Very High Very High Very High
Potency 2 98.72 Very High Very High Very High
antagonist 16 97.42 Very High Very High Very High
agonist 3 91.20 High High
opiate 1 86.40 High High
Catecholamine 1 84.08 Quite High
Disease Link Frequency Relevance Heat
Precocious Puberty 2 90.40 High High
Cancer 2 84.96 Quite High
Acromegaly 1 82.32 Quite High
Hyperplasia 1 80.16 Quite High
Targeted Disruption 1 78.48 Quite High
Catalepsy 1 65.36 Quite High
Adenoma 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of somatostatin and hypothalamic ventromedial lesions on GH release induced by morphine.
Regulation (Effects) of Localization (release) of GH associated with somatostatin and morphine
1) Confidence 0.58 Published 1975 Journal Endocrinology Section Title Doc Link 123501 Disease Relevance 0 Pain Relevance 0.54
Propranolol (1-100 microM) had no significant effect on basal GH secretion or GH secretion stimulated by rat GRF.
Neg (no) Regulation (effect) of Localization (secretion) of GH
2) Confidence 0.50 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.88
Propranolol (1-100 microM) had no significant effect on basal GH secretion or GH secretion stimulated by rat GRF.
Neg (no) Regulation (effect) of Localization (secretion) of GH
3) Confidence 0.50 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.88
In conclusion, 1) beta-adrenergic antagonists caused inhibition of stimulated SRIF release; 2) clonidine had no detectable effect on SRIF release; and 3) propranolol did not affect GH secretion in vitro.
Neg (not) Regulation (affect) of Localization (secretion) of GH associated with antagonist, somatostatin and clonidine
4) Confidence 0.50 Published 1990 Journal Endocrinology Section Abstract Doc Link 1967576 Disease Relevance 0 Pain Relevance 0.86
In vitro, clonidine had no stimulatory effect on GHRH-stimulated GH secretion.
Neg (no) Regulation (effect) of Localization (secretion) of GH associated with clonidine
5) Confidence 0.35 Published 1989 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 2514051 Disease Relevance 0 Pain Relevance 1.17
Growth Hormone-Releasing Hormone (GHRH) is the main factor, which regulates GH secretion and somatotrope proliferation.
Regulation (regulates) of Localization (secretion) of GH in somatotrope
6) Confidence 0.16 Published 2005 Journal Endokrynol Pol Section Abstract Doc Link 16821213 Disease Relevance 0.40 Pain Relevance 0
Under the same conditions, the secretion of GH, LH, FSH was not affected.
Neg (not) Regulation (affected) of Localization (secretion) of GH
7) Confidence 0.10 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 7413020 Disease Relevance 0 Pain Relevance 0.16
The potent stimulant effect of sauvagine on ACTH and beta-endorphin release has been confirmed both in vivo and on columns of isolated and dispersed rat pituitary cells, and similarly the potent inhibitory effect on PRL and GH release, both in the rat and man.
Regulation (effect) of Localization (release) of GH in pituitary
8) Confidence 0.09 Published 1981 Journal Peptides Section Abstract Doc Link 6178095 Disease Relevance 0.07 Pain Relevance 0.10
The stimulatory effect of PRL-ME implants could not be attributed to alterations in the release of LH, FSH, GH or TSH from the anterior pituitary.
Regulation (alterations) of Localization (release) of GH in anterior pituitary
9) Confidence 0.08 Published 1982 Journal Brain Res. Bull. Section Abstract Doc Link 6811105 Disease Relevance 0.17 Pain Relevance 0.20
While chronic administration of morphine results in tolerance to the stimulant effect of ACTH, and possibly of prolactin secretion, tolerance does not develop to the stimulant effect on GH secretion.
Regulation (effect) of Localization (secretion) of GH associated with tolerance and morphine
10) Confidence 0.04 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6110621 Disease Relevance 0 Pain Relevance 1.20

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