INT100202

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ggta1) Golgi apparatus (Ggta1) carbohydrate metabolic process (Ggta1)
Anatomy Link Frequency
endothelial cells 1
Ggta1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 1 75.44 Quite High
palliative 1 75.04 Quite High
Peripheral nervous system 2 63.04 Quite High
Eae 1 51.76 Quite High
hypoalgesia 2 49.52 Quite Low
Sciatic nerve 1 35.04 Quite Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Metabolic Disorder 1 99.74 Very High Very High Very High
Fabry Disease 10 99.06 Very High Very High Very High
Angiokeratoma 1 86.88 High High
Death 1 85.68 High High
Neuropathic Pain 1 75.44 Quite High
Targeted Disruption 2 75.00 Quite High
Congenital Anomalies 1 75.00 Quite High
Lysosomal Storage Diseases 1 71.52 Quite High
Hypoalagesia 2 49.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fabry disease is an X-linked metabolic disorder caused by a deficiency of alpha-galactosidase A (alpha-Gal A).
Negative_regulation (deficiency) of alpha-Gal associated with metabolic disorder and fabry disease
1) Confidence 0.41 Published 2001 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 11758676 Disease Relevance 0.43 Pain Relevance 0.08
Loss of alpha-galactosidase (alpha-Gal) activity leads to the abnormal accumulation of glycosphingolipids in lysosomes predominantly of vascular endothelial cells.
Negative_regulation (Loss) of alpha-Gal in endothelial cells
2) Confidence 0.37 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 18848893 Disease Relevance 0.47 Pain Relevance 0.13

General Comments

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