INT100221

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Context Info
Confidence 0.24
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
neurons 2
epithelial cell 2
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.68 Very High Very High Very High
cINOD 7 96.66 Very High Very High Very High
nMDA receptor 31 92.20 High High
long-term potentiation 5 72.20 Quite High
depression 8 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 99.60 Very High Very High Very High
Stress 2 99.44 Very High Very High Very High
Ulcers 2 84.08 Quite High
INFLAMMATION 2 81.08 Quite High
Wound Healing 1 69.20 Quite High
Depression 8 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Genetic Translocation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increases in tyrosine phosphorylation at both the inhibitory and activation tyrosine residues of Src in the hippocampus suggest the intriguing possibility that two or more pools of Src may be present in neurons as well.
Negative_regulation (residues) of Phosphorylation (phosphorylation) of Src in neurons associated with hippocampus
1) Confidence 0.24 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.35
Using a wounded gastric epithelial cell monolayer model, we demonstrated that NSAIDs reduce both basal and epidermal growth factor (EGF)-induced re-epithelialization, and that this action involves disruption of actin stress fiber formation, reduced c-Src activity, decreased phosphorylation of focal adhesion kinase (FAK), tensin and their cellular re-distribution.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Src in epithelial cell associated with stress, cinod and adhesions
2) Confidence 0.03 Published 2001 Journal Life Sci. Section Abstract Doc Link 11758831 Disease Relevance 0.74 Pain Relevance 0.58

General Comments

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