INT100222

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.41
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
spinal 1
neurons 1
brain 1
dorsal horns 1
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 120 100.00 Very High Very High Very High
long-term potentiation 8 99.76 Very High Very High Very High
spinal dorsal horn 4 99.68 Very High Very High Very High
cINOD 7 98.74 Very High Very High Very High
intrathecal 49 98.62 Very High Very High Very High
Spinal cord 90 98.16 Very High Very High Very High
Dorsal horn neuron 19 97.02 Very High Very High Very High
Morphine 4 96.40 Very High Very High Very High
Inflammation 40 95.60 Very High Very High Very High
Dorsal horn 35 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 98.62 Very High Very High Very High
Hypertension 6 98.48 Very High Very High Very High
Ulcers 2 96.64 Very High Very High Very High
Wound Healing 1 95.84 Very High Very High Very High
Hemolytic Anemia 6 94.64 High High
Renal Disease 33 94.24 High High
Fibrosis 12 92.40 High High
Hyperalgesia 79 90.12 High High
Adhesions 2 87.68 High High
Systemic Sclerosis 90 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At such late stages, it is often difficult to distinguish chronic vascular changes associated with organized SRC from preexisting chronic accelerated essential hypertension.
SRC Binding (associated) of associated with hypertension
1) Confidence 0.26 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 0.83 Pain Relevance 0.09
The mortality associated with SRC has significantly decreased due to early diagnosis and aggressive angiotensin-converting enzyme (ACE) inhibitor therapy [50, 51].
SRC Binding (associated) of
2) Confidence 0.26 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 0.69 Pain Relevance 0
Anti-U3 RNP antibodies were found to have an association with SRC in some [23] but not all [24] studies.
SRC Binding (association) of
3) Confidence 0.25 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 0.59 Pain Relevance 0.06
Coimmunoprecipitation indicates that Shank, a postsynaptic density protein associated with mGluRs, formed a complex involving PSD-95 (postsynaptic density-95), NR2B, and Src in the spinal dorsal horn.
Src Binding (complex) of in spinal associated with spinal dorsal horn
4) Confidence 0.24 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.59 Pain Relevance 1.20
Src is brought into proximity of the NMDA receptors through its binding to ND2, a protein which serves as a structural and morphological scaffold for the regulation of NMDA receptors by Src [6].
Src Binding (binding) of associated with nmda receptor
5) Confidence 0.21 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.15 Pain Relevance 0.63
The mechanism apparently involved Src family kinases, since the level of phospho-Src bound to EphB receptors in the dorsal horns of the spinal cord was increased.
phospho-Src Binding (bound) of in dorsal horns associated with spinal cord
6) Confidence 0.17 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.65 Pain Relevance 1.06
We did not reprobe for amounts of total Src/Fyn/Yes as total levels of those proteins bound to NR2B are directly affected by phosphorylation, i.e. phosphorylation promotes the association of the proteins to NR2B (Yu et al., 1997); the ratio of phospho-Src/total Src could thus potentially remain constant despite a significant increase in the total amount of activated phospho-Src bound to NR2B.
phospho-Src Binding (bound) of
7) Confidence 0.17 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.18 Pain Relevance 0.26
Our findings (Battaglia et al., 2003, and present work) support the idea of an activation by ephrinB2 of postsynaptic EphB receptors in neurons of the dorsal horn, since we showed that EphB1 receptors are present in dorsal horn neurons, where they are found in close association with NMDA receptors, and intrathecal administration of ephrinB2-Fc induces an increase in phosphorylated Src kinase associated with the EphB receptor itself.
Src Binding (associated) of in neurons associated with nmda receptor, dorsal horn, dorsal horn neuron and intrathecal
8) Confidence 0.17 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.01 Pain Relevance 0.91
We have found that in the absence of MOR activation, the brain specific Galphaz subunit binds to and stabilizes Src in its inactive form.
Src Binding (stabilizes) of in brain
9) Confidence 0.09 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19446022 Disease Relevance 0 Pain Relevance 0.35
This was achieved by PKCgamma disrupting this Galphaz-Src complex, enabling Src to be activated (pTyr416) by binding to GalphaiGTP proteins.
Galphaz-Src Binding (complex) of
10) Confidence 0.08 Published 2009 Journal Cell. Signal. Section Abstract Doc Link 19446022 Disease Relevance 0 Pain Relevance 0.36
Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, and tensin signaling.
Src Binding (interfering) of associated with inflammation and cinod
11) Confidence 0.03 Published 2001 Journal Life Sci. Section Title Doc Link 11758831 Disease Relevance 0.73 Pain Relevance 0.45

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