INT100247

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B) signal transduction (PDE1B) nucleolus (PDE1B)
nucleus (PDE1B) cytoplasm (PDE1B)
PDE1B (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 1 74.16 Quite High
headache 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Overactive Bladder 5 98.02 Very High Very High Very High
Reprotox - General 2 1 86.20 High High
Incontinence 2 78.96 Quite High
Interstitial Cystitis 1 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrate the presence of five PDE isoenzymes in human detrusor and suggest, for the first time, that the cAMP pathway and the calcium/calmodulin-stimulated PDE (PDE 1) are of functional importance in the intracellular regulation in this tissue in vitro.
Positive_regulation (importance) of PDE 1 associated with overactive bladder
1) Confidence 0.40 Published 2001 Journal World J Urol Section Abstract Doc Link 11760783 Disease Relevance 0.65 Pain Relevance 0.07
The current study investigates possible NO modulation of cGMP-related PDEs relevant to headache induction in a cell line containing such PDEs.
Positive_regulation (induction) of PDEs
2) Confidence 0.09 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0

General Comments

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