INT100251

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE1B) signal transduction (PDE1B) nucleolus (PDE1B)
nucleus (PDE1B) cytoplasm (PDE1B)
Anatomy Link Frequency
smooth muscle 1
PDE1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 9 80.92 Quite High
interstitial cystitis 2 76.72 Quite High
long-term potentiation 17 72.20 Quite High
Central nervous system 13 62.96 Quite High
Neurotransmitter 8 23.92 Low Low
Inflammation 42 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overactive Bladder 10 98.02 Very High Very High Very High
Reprotox - General 2 14 88.48 High High
Incontinence 4 81.52 Quite High
Interstitial Cystitis 2 76.72 Quite High
INFLAMMATION 48 5.00 Very Low Very Low Very Low
Pulmonary Disease 31 5.00 Very Low Very Low Very Low
Disease 26 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 20 5.00 Very Low Very Low Very Low
Demyelinating Disease 7 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because of their central role in the intracellular regulation of smooth muscle tone phosphodiesterases (PDEs) are an attractive pharmacological targets.
Regulation (regulation) of PDEs in smooth muscle
1) Confidence 0.26 Published 2001 Journal World J Urol Section Abstract Doc Link 11760783 Disease Relevance 0.55 Pain Relevance 0
Our data demonstrate the presence of five PDE isoenzymes in human detrusor and suggest, for the first time, that the cAMP pathway and the calcium/calmodulin-stimulated PDE (PDE 1) are of functional importance in the intracellular regulation in this tissue in vitro.
Regulation (regulation) of PDE 1 associated with overactive bladder
2) Confidence 0.23 Published 2001 Journal World J Urol Section Abstract Doc Link 11760783 Disease Relevance 0.66 Pain Relevance 0.08
The N-terminal domain shows great diversity between PDE families (Figure 1) and understanding the functional relevance of the differences in the N-terminal domains is crucial to understanding the regulation and sub-cellular localization of different PDEs and to the development of drugs that modulate PDE activity.
Regulation (regulation) of PDEs
3) Confidence 0.06 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
PDEs are regulated by means of 3 principal mechanisms: i) Availability of the substrate, such as the stimulation of PDE activity after the increase of the levels of cyclic nucleotides or after alteration of the ratio of hydrolysis between one nucleotide and another; ii) Regulation of the intracellular signal by extracellular signals (ie, phosphorylation); iii) Feedback regulation (Corbin and Francis 1999).


Regulation (regulated) of PDEs
4) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0 Pain Relevance 0.14

General Comments

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