INT100254

Context Info Confidence 0.36 First Reported 2001 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.54 Pain Relevance 0.40

endoplasmic reticulum (SELS) plasma membrane (SELS) enzyme binding (SELS) cytoplasm (SELS)

Anatomy Link Frequency liver 1 neural 1 SELS (Homo sapiens)

Pain Link Frequency Relevance Heat epidural 1 88.04 anesthesia 2 85.92 Transcranial magnetic stimulation 3 80.72 ketamine 2 75.00 Action potential 1 57.20 Inflammation 16 30.64 Angina 16 5.00 cytokine 8 5.00 Inflammatory marker 6 5.00 rheumatoid arthritis 2 5.00

Disease Link Frequency Relevance Heat Disease 52 100.00 Stroke 136 99.78 Insulin Resistance 12 98.20 Cardiovascular Disease 290 97.40 Obesity 174 97.16 Coronary Artery Disease 202 97.12 Diabetes Mellitus 46 95.56 Familial Combined Hyperlipidemia 4 94.32 Disorder Of Lipid Metabolism 88 79.88 Metabolic Syndrome 14 73.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recording of both neural D- and I- MEPs and SEPs is feasible under high sole i.v.

SEPs Binding (Recording) of in neural

1) Confidence 0.36 Published 2001 Journal Neurol. Res. Section Abstract Doc Link 11760882 Disease Relevance 0 Pain Relevance 0.40

The associations between SELS genotype and BP in the whole cohort remained significant also when omitting subjects on antihypertensive treatment.

SELS Binding (associations) of

2) Confidence 0.33 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 0.16 Pain Relevance 0

It has been speculated that the interaction between the SAA1 protein and the putative receptor SELS [6] could be involved in the development of insulin resistance, and a recent study in rats showed that the expression level of SELS in liver was higher in diabetic rats compared with both healthy rats and diabetic rats treated with the insulin sensitizer rosiglitazone [25].

SELS Binding (interaction) of in liver associated with diabetes mellitus and insulin resistance

3) Confidence 0.31 Published 2011 Journal Metabolism Section Body Doc Link PMC3004038 Disease Relevance 1.46 Pain Relevance 0

The gender-genotype interaction analysis supports our previous findings for USF1 and SEPS1 variants in which the disease risk was limited to women [30], [31], providing a gender-genotype interaction p-values<0.01 for the USF1 variant rs2774279 and for two SEPS1 variants, rs4965814 and rs9874.

SEPS1 Binding (findings) of associated with disease

4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.42 Pain Relevance 0

For ischemic stroke, only one SEPS1 variant, rs7178239, was associated at p?

SEPS1 Binding (associated) of associated with stroke

5) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.81 Pain Relevance 0

The gender-genotype interaction analysis supports our previous findings for USF1 and SEPS1 variants in which the disease risk was limited to women [30], [31], providing a gender-genotype interaction p-values<0.01 for the USF1 variant rs2774279 and for two SEPS1 variants, rs4965814 and rs9874.

SEPS1 Binding (findings) of associated with disease

6) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.65 Pain Relevance 0

For ischemic stroke, we identified a variant in F5 as conferring gender-specific risk, in addition to our previously reported association between SEPS1 variants and ischemic stroke in women [30].

SEPS1 Binding (association) of associated with stroke

7) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 1.05 Pain Relevance 0

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