INT100256

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.41
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
IEC-6 2
fibroblast 2
lungs 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 31 99.74 Very High Very High Very High
Inflammatory response 10 99.48 Very High Very High Very High
Inflammation 229 96.72 Very High Very High Very High
substance P 22 95.60 Very High Very High Very High
Antinociceptive 2 95.48 Very High Very High Very High
Nicotine 192 92.72 High High
Inflammatory mediators 10 91.20 High High
aspirin 4 88.16 High High
B1 receptor 14 85.40 High High
b2 receptor 58 82.92 Quite High
Disease Link Frequency Relevance Heat
Cancer 15 99.84 Very High Very High Very High
Necrosis 12 99.56 Very High Very High Very High
INFLAMMATION 251 99.28 Very High Very High Very High
Cough 4 94.16 High High
Pressure And Volume Under Development 4 93.76 High High
Encephalitis 2 93.76 High High
Apoptosis 13 92.24 High High
Parkinson's Disease 108 90.36 High High
Sprains And Strains 18 89.84 High High
Injury 23 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of NF-kappaB associated with necrosis and cancer
1) Confidence 0.49 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
Here we demonstrate that transcription from a promoter containing NF-kappaB binding sequences as well as the DNA binding activity of NF-kappaB were increased in PDGF-B-chain-transformed mouse fibroblast cells.
Positive_regulation (increased) of Transcription (transcription) of NF-kappaB in fibroblast
2) Confidence 0.46 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 11855867 Disease Relevance 0.25 Pain Relevance 0.17
B-p50 mRNA expression was significantly increased with exposure in Ppar?
Positive_regulation (increased) of Transcription (expression) of p50
3) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.17 Pain Relevance 0
To determine whether activation of NK1R increases the transcriptional activities of NF-kappaB and Nkx-2.5, an EMSA was performed.
Spec (whether) Positive_regulation (increases) of Transcription (transcriptional) of NF-kappaB
4) Confidence 0.24 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
Furthermore, increased levels of ROS have been implicated in initiating inflammatory responses in the lungs through the activation of transcription factors such as nuclear factor-kappaB (NF-?
Positive_regulation (activation) of Transcription (transcription) of nuclear factor-kappaB in lungs associated with inflammatory response
5) Confidence 0.16 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.56 Pain Relevance 0.13
NSAIDs are able to inactivate the transcription NF-kB and activator protein-1 (AP-1), critically involved in the induction of multiple inflammatory gene products involved in the inflammatory response (i.e. iNOS, TNF-?).
Positive_regulation (inactivate) of Transcription (transcription) of NF-kB associated with inflammatory response, inflammation and cinod
6) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.61 Pain Relevance 0.47
Dexamethasone inhibited interleukin-1beta induced, NF-kappaB driven gene transcription only in IEC-6 and not in Caco-2 cells.
Positive_regulation (induced) of Transcription (transcription) of NF-kappaB in IEC-6
7) Confidence 0.07 Published 2001 Journal Int J Colorectal Dis Section Body Doc Link 11760899 Disease Relevance 0 Pain Relevance 0
The mechanism behind AHR to kinins appears to involve activation of intracellular MAPKs and the down-stream transcription factor nuclear factor-kappaB (NF-?
Positive_regulation (activation) of Transcription (transcription) of factor nuclear factor-kappaB
8) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.64 Pain Relevance 0.54
The mechanism behind AHR to kinins appears to involve activation of intracellular MAPKs and the down-stream transcription factor nuclear factor-kappaB (NF-?
Positive_regulation (behind) of Transcription (transcription) of factor nuclear factor-kappaB
9) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.65 Pain Relevance 0.55

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