INT100274

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.79
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN, IL1B) extracellular region (IL1RN, IL1B) aging (IL1B)
intracellular (IL1RN) cell-cell signaling (IL1B) cytoplasm (IL1RN)
Anatomy Link Frequency
cartilage 2
IL1RN (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 13 100.00 Very High Very High Very High
Osteoarthritis 10 99.74 Very High Very High Very High
cytokine 21 98.32 Very High Very High Very High
Central nervous system 1 91.48 High High
Inflammation 28 90.00 High High
cINOD 2 75.76 Quite High
Pain 4 75.00 Quite High
aspirin 4 73.28 Quite High
chemokine 1 69.88 Quite High
Inflammatory response 5 63.64 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 8 99.74 Very High Very High Very High
Disease 11 99.24 Very High Very High Very High
Fever 1 97.56 Very High Very High Very High
INFLAMMATION 35 90.00 High High
Cardiovascular Disease 3 89.76 High High
Thrombosis Related Under Development 1 84.56 Quite High
Obesity 1 78.48 Quite High
Stress 1 76.80 Quite High
Knee Osteoarthritis 2 75.00 Quite High
Rheumatic Diseases 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In animal models of OA, IL-1 blockade by IL-1 receptor antagonist (IL-1Ra) can slow the progression of disease.
IL-1 receptor antagonist Negative_regulation (blockade) of IL-1 associated with antagonist, disease and osteoarthritis
1) Confidence 0.53 Published 2005 Journal J. Rheumatol. Section Abstract Doc Link 15996071 Disease Relevance 0.47 Pain Relevance 0.39
In animal models of OA, IL-1 blockade by IL-1 receptor antagonist (IL-1Ra) can slow the progression of disease.
IL-1Ra Negative_regulation (blockade) of IL-1 associated with antagonist, disease and osteoarthritis
2) Confidence 0.53 Published 2005 Journal J. Rheumatol. Section Abstract Doc Link 15996071 Disease Relevance 0.47 Pain Relevance 0.39
is IL-1ra, a naturally occurring inhibitor of IL-1?
IL-1ra Negative_regulation (inhibitor) of IL-1
3) Confidence 0.48 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.67 Pain Relevance 0.37
OBJECTIVE: Interleukin 1 receptor antagonist (IL-1Ra) may play an important role in cartilage degradation by inhibiting IL-1 activity and therefore blocking IL-1 stimulation of prostaglandin E2 (PGE2) synthesis.
Interleukin 1 receptor antagonist Negative_regulation (inhibiting) of IL-1 in cartilage associated with antagonist
4) Confidence 0.35 Published 2001 Journal J. Rheumatol. Section Abstract Doc Link 11764219 Disease Relevance 0.09 Pain Relevance 0.24
OBJECTIVE: Interleukin 1 receptor antagonist (IL-1Ra) may play an important role in cartilage degradation by inhibiting IL-1 activity and therefore blocking IL-1 stimulation of prostaglandin E2 (PGE2) synthesis.
IL-1Ra Negative_regulation (inhibiting) of IL-1 in cartilage associated with antagonist
5) Confidence 0.26 Published 2001 Journal J. Rheumatol. Section Abstract Doc Link 11764219 Disease Relevance 0.09 Pain Relevance 0.24

General Comments

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