INT100277

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Context Info
Confidence 0.19
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.90
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TBL1XR1) small molecule metabolic process (TBL1XR1) histone binding (TBL1XR1)
nucleolus (TBL1XR1) nucleus (TBL1XR1) DNA binding (TBL1XR1)
Anatomy Link Frequency
chondrocytes 2
PGE2 2
TBL1XR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 2 99.96 Very High Very High Very High
psoriasis 2 64.04 Quite High
Pain 74 57.64 Quite High
antagonist 4 50.00 Quite Low
aspirin 5 10.00 Low Low
Inflammation 19 5.00 Very Low Very Low Very Low
Analgesic 12 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 2 99.96 Very High Very High Very High
Contusions 2 99.68 Very High Very High Very High
Disease 2 95.60 Very High Very High Very High
Low Back Pain 3 95.20 Very High Very High Very High
Ulcers 108 88.08 High High
Wound Healing 80 85.92 High High
Basal Cell Carcinoma 2 82.84 Quite High
Keratosis 2 80.68 Quite High
Hypoxia 2 79.32 Quite High
Injury 125 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Working mechanisms of wIRA
Positive_regulation (mechanisms) of Gene_expression (mechanisms) of wIRA
1) Confidence 0.19 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 0.07 Pain Relevance 0
Bechterew [77], arthroses, arthritises, contusions; fibromyalgia (preferably wIRA in combination with motion, i.e. wIRA with a small amount of ergometer work) [93], regeneration after sports [78] (wIRA alone or wIRA in combination with motion), postoperative rehabilitation [89], [94], improvement of lipolysis (wIRA in combination with motion) [61].
Positive_regulation (preferably) of Gene_expression (preferably) of wIRA associated with contusions and fibrositis
2) Confidence 0.16 Published 2007 Journal GMS Krankenhaushygiene Interdisziplinar Section Body Doc Link PMC2831244 Disease Relevance 1.19 Pain Relevance 0.08
A typical image of the stratum corneum after application of the fluorescein sodium containing formulation, without wIRA irradiation, is presented in Figure 6a (Fig. 6).
Positive_regulation (presented) of Gene_expression (irradiation) of wIRA
3) Confidence 0.12 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703260 Disease Relevance 0 Pain Relevance 0
Working mechanisms of wIRA
Positive_regulation (mechanisms) of Gene_expression (mechanisms) of wIRA
4) Confidence 0.05 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.64 Pain Relevance 0.16
Aceclofenac may modulate PGE2 production by increasing IL-IRa production and decreasing NO synthesis.
Positive_regulation (increasing) of Gene_expression (production) of IL-IRa in PGE2
5) Confidence 0.04 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Proinflammatory stimuli induce IL-IRa synthesis in human articular chondrocytes.
Positive_regulation (induce) of Gene_expression (synthesis) of IL-IRa in chondrocytes
6) Confidence 0.04 Published 2001 Journal J. Rheumatol. Section Body Doc Link 11764219 Disease Relevance 0 Pain Relevance 0

General Comments

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