INT100279

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) nucleoplasm (TXN) transport (TXN)
mitochondrion (TXN) small molecule metabolic process (TXN) response to stress (HSP90B2P)
Anatomy Link Frequency
keratinocytes 2
TXN (Homo sapiens)
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 91.20 High High
Neuropeptide 1 80.88 Quite High
cytokine 1 67.92 Quite High
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Death 1 100.00 Very High Very High Very High
Stress 2 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, addition of an antibody against TRX induced cell death in keratinocytes, probably due to enhanced signaling of MSH, as it has been shown that MSH suppresses heat shock protein (hsp) 70 expression in differentiated keratinocytes, which express high levels of MC1-R and decreases their survival rate during oxidative stress.
TRX Negative_regulation (suppresses) of Gene_expression (expression) of hsp in keratinocytes associated with stress, shock and death
1) Confidence 0.13 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.30 Pain Relevance 0.24

General Comments

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