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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) signal transducer activity (MC1R) cell-cell signaling (TXN)
Anatomy Link Frequency
keratinocytes 2
TXN (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2 100.00 Very High Very High Very High
cytokine 1 78.28 Quite High
Neuropeptide 1 51.76 Quite High
Disease Link Frequency Relevance Heat
Death 1 82.56 Quite High
Shock 1 73.52 Quite High
Stress 2 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
TRX Positive_regulation (upregulated) of Gene_expression (expression) of MC1-R in keratinocytes associated with melanocortin 1 receptor
1) Confidence 0.33 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.22 Pain Relevance 0.24

General Comments

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