INT100283

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Context Info
Confidence 0.54
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.50
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TXN, POMC) cell-cell signaling (TXN, POMC) cytoplasm (TXN, POMC)
signal transduction (TXN, POMC) extracellular region (TXN, POMC) nucleoplasm (TXN)
Anatomy Link Frequency
keratinocytes 8
TXN (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 8 95.12 Very High Very High Very High
cytokine 4 88.44 High High
Neuropeptide 4 38.64 Quite Low
Disease Link Frequency Relevance Heat
Death 4 69.44 Quite High
Shock 4 60.40 Quite High
Stress 8 48.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
TRX Negative_regulation (suppressed) of Gene_expression (production) of ACTH in keratinocytes associated with melanocortin 1 receptor
1) Confidence 0.54 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.13 Pain Relevance 0.21
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
TRX Negative_regulation (suppressed) of Gene_expression (production) of alpha-melanocyte stimulating hormone in keratinocytes associated with melanocortin 1 receptor
2) Confidence 0.40 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.12 Pain Relevance 0.21
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
TRX Negative_regulation (suppressed) of Gene_expression (production) of adrenocorticotropic hormone in keratinocytes associated with melanocortin 1 receptor
3) Confidence 0.40 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.13 Pain Relevance 0.21
TRX suppressed the UVB-induced production and secretion of alpha-melanocyte stimulating hormone (alpha-MSH) and of adrenocorticotropic hormone (ACTH), and also suppressed proopiomelanocortin (POMC) mRNA expression by normal human keratinocytes; however, TRX upregulated melanocortin 1 receptor (MC1-R) expression synergistically with UVB in normal human keratinocytes.
TRX Negative_regulation (suppressed) of Gene_expression (production) of MSH in keratinocytes associated with melanocortin 1 receptor
4) Confidence 0.40 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.12 Pain Relevance 0.21

General Comments

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