INT100287

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.62
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TXN) transport (TXN) mitochondrion (TXN)
small molecule metabolic process (TXN) cell-cell signaling (TXN) cytoplasm (TXN)
Anatomy Link Frequency
keratinocytes 2
T-cell 1
TXN (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 98.56 Very High Very High Very High
cytokine 5 90.68 High High
melanocortin 1 receptor 4 77.08 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 99.24 Very High Very High Very High
Lymphatic System Cancer 7 97.68 Very High Very High Very High
Leukemia 2 97.08 Very High Very High Very High
Shock 2 91.28 High High
Death 2 86.76 High High
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Viral Infection 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4E, murine CD30 expressed on the Rauscher murine leukemia virus-induced T-cell lymphoma line RMA is efficiently targeted by Trx1(CSAAA), thus demonstrating that the additional CRDs in human CD30 are not required for Trx1 reactivity.
Neg (not) Regulation (required) of Trx1 in T-cell associated with leukemia and lymphatic system cancer
1) Confidence 0.41 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0.19 Pain Relevance 0
The purpose of this study was to examine the effects of TRX on keratinocytes as an autocrine factor.
Spec (examine) Regulation (effects) of TRX in keratinocytes
2) Confidence 0.37 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.05 Pain Relevance 0.20
Taken together, the results suggest that keratinocyte-derived TRX regulates the expression of stress inducible neuropeptides and their receptor, and is critically involved in the survival of keratinocytes.
Regulation (regulates) of TRX in keratinocytes associated with stress and neuropeptide
3) Confidence 0.37 Published 2001 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11764282 Disease Relevance 0.37 Pain Relevance 0.23

General Comments

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