INT100294

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Context Info
Confidence 0.46
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 5.41
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp7) anatomical structure formation involved in morphogenesis (Bmp7) extracellular space (Bmp7)
growth (Bmp7) extracellular region (Bmp7)
Anatomy Link Frequency
lens 6
ruga 2
lens epithelium 2
teeth 2
dental pulps 2
Bmp7 (Mus musculus)
Pain Link Frequency Relevance Heat
pulpitis 4 96.56 Very High Very High Very High
anesthesia 7 79.00 Quite High
Eae 14 43.20 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 5 99.84 Very High Very High Very High
Injury 20 99.12 Very High Very High Very High
Metastasis 12 98.64 Very High Very High Very High
Infection 8 96.92 Very High Very High Very High
Cancer 57 96.56 Very High Very High Very High
Pulpitis 4 96.56 Very High Very High Very High
Recurrence 1 96.32 Very High Very High Very High
Adenocarcinoma 2 91.20 High High
Lung Cancer 2 90.12 High High
Breast Cancer 3 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also studied the expression of a member of the family of the bone morphogenetic proteins (BMPs), Bmp7, that reportedly regulates energy homeostasis by activating a full program of brown adipogenesis [48]. iNOS deficiency enhanced Bmp7 protein expression.
Positive_regulation (enhanced) of Gene_expression (expression) of Bmp7 protein
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.83 Pain Relevance 0
Nevertheless, protein expression levels of Bmp7 were increased in mice lacking the iNOS gene.
Positive_regulation (increased) of Gene_expression (expression) of Bmp7
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.78 Pain Relevance 0
BMP-7 gene transfer to inflamed ferret dental pulps.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7 in dental pulps
3) Confidence 0.38 Published 2001 Journal Eur. J. Oral Sci. Section Title Doc Link 11767280 Disease Relevance 0.16 Pain Relevance 0.15
E. vivo gene transfer of BMP-7 may be an effective method for inducing dentin regeneration in teeth with reversible pulpitis.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7 in teeth associated with pulpitis
4) Confidence 0.38 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11767280 Disease Relevance 0.27 Pain Relevance 0.17
We noticed that Bmp7 expression was turned on late during formation of one ruga (just as Shh).
Positive_regulation (turned) of Gene_expression (expression) of Bmp7 in ruga
5) Confidence 0.38 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Exogenous BMP-7 upregulated expression of Id2 and Id3 in injured lenses, and gene introduction of Id2 or Id3 also upregulated BMP-7 expression.
Positive_regulation (upregulated) of Gene_expression (expression) of BMP-7 in lenses
6) Confidence 0.24 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of the lens epithelial cells as evaluated by histology and expression patterns of alpha-smooth muscle actin and collagens in association with reduction of Smad2 COOH-terminal phosphorylation.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7 in lens associated with injury
7) Confidence 0.24 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of lens epithelial cells and subsequent sealing of the capsular break with fibrous tissue in mice.
Positive_regulation (transfer) of Gene_expression (transfer) of BMP-7 in lens associated with injury
8) Confidence 0.24 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.33 Pain Relevance 0.07
We have examined the effect of adenovirus-mediated expression of bone morphogenic protein-7 (BMP-7) and inhibitors of differentiation 2 and 3 (Id2 and Id3) on injury-induced epithelial-to-mesenchymal transition (EMT) of lens epithelium in mice.
Spec (examined) Positive_regulation (mediated) of Spec (examined) Gene_expression (expression) of BMP-7 in lens epithelium associated with injury
9) Confidence 0.22 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.24 Pain Relevance 0.06
Bone morphogenic proteins can also serve as prognostic markers, since the BMP-7 expression is increased in malignant melanomas and their metastases, which correlates with a shorter time to tumor recurrence [45].
Positive_regulation (increased) of Gene_expression (expression) of BMP-7 associated with cancer, melanoma, recurrence and metastasis
10) Confidence 0.08 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 2.19 Pain Relevance 0

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