INT100295

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 14.34
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp7) anatomical structure formation involved in morphogenesis (Bmp7) extracellular space (Bmp7)
growth (Bmp7) extracellular region (Bmp7)
Anatomy Link Frequency
tendon 3
lens 3
lens epithelium 3
ruga 2
bursa 1
Bmp7 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 44 99.68 Very High Very High Very High
imagery 17 99.56 Very High Very High Very High
antagonist 43 98.36 Very High Very High Very High
diclofenac 10 98.22 Very High Very High Very High
pulpitis 4 96.56 Very High Very High Very High
cytokine 56 92.76 High High
Inflammation 213 92.36 High High
cINOD 62 88.00 High High
anesthesia 14 78.52 Quite High
Snapping jaw 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 179 99.54 Very High Very High Very High
Reprotox - General 1 26 99.38 Very High Very High Very High
Melanoma 5 99.32 Very High Very High Very High
Injury 55 99.12 Very High Very High Very High
Metastasis 57 98.12 Very High Very High Very High
Fracture Healing 12 97.86 Very High Very High Very High
Obesity 477 96.96 Very High Very High Very High
Infection 14 96.92 Very High Very High Very High
Neurodegenerative Disease 256 96.60 Very High Very High Very High
Pulpitis 4 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Poly-l-lactic acid/hydroxyapatite composite scaffolds were differentially seeded with fibroblasts transduced with an adenovirus expressing bone morphogenetic protein-7 in the ceramic phase and fully differentiated chondrocytes in the polymeric phase, and were subcutaneously implanted into mice.
Gene_expression (expressing) of bone morphogenetic protein-7 in fibroblasts
1) Confidence 0.78 Published 2005 Journal Orthod Craniofac Res Section Abstract Doc Link 16238612 Disease Relevance 0.36 Pain Relevance 0.07
Therefore, we first analyzed fracture healing in control and diclofenac-treated mice, where we not only found a significant impairment of fracture healing due to diclofenac treatment as assessed by biomechanical testing and microCT imaging, but also found high coexpression of bone morphogenetic protein-7 (BMP-7) and cyclooxygenase-2 (COX-2) within the fracture callus of both groups.
Gene_expression (coexpression) of BMP-7 associated with fracture healing, imagery and diclofenac
2) Confidence 0.78 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20063306 Disease Relevance 0.48 Pain Relevance 0.55
Therefore, we first analyzed fracture healing in control and diclofenac-treated mice, where we not only found a significant impairment of fracture healing due to diclofenac treatment as assessed by biomechanical testing and microCT imaging, but also found high coexpression of bone morphogenetic protein-7 (BMP-7) and cyclooxygenase-2 (COX-2) within the fracture callus of both groups.
Gene_expression (coexpression) of bone morphogenetic protein-7 associated with fracture healing, imagery and diclofenac
3) Confidence 0.78 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20063306 Disease Relevance 0.48 Pain Relevance 0.55
We also studied the expression of a member of the family of the bone morphogenetic proteins (BMPs), Bmp7, that reportedly regulates energy homeostasis by activating a full program of brown adipogenesis [48]. iNOS deficiency enhanced Bmp7 protein expression.
Gene_expression (expression) of Bmp7
4) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.90 Pain Relevance 0.03
We also studied the expression of a member of the family of the bone morphogenetic proteins (BMPs), Bmp7, that reportedly regulates energy homeostasis by activating a full program of brown adipogenesis [48]. iNOS deficiency enhanced Bmp7 protein expression.
Gene_expression (expression) of Bmp7 protein
5) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.83 Pain Relevance 0
In contrast, we found that Bmp7 is expressed at the tip of the primitive rugae, in a pattern very similar to Shh.
Gene_expression (expressed) of Bmp7
6) Confidence 0.63 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.05 Pain Relevance 0
Later on, Shh and Bmp7 become expressed at the tip of the newly formed ruga, and a true gap is formed.
Gene_expression (expressed) of Bmp7 in ruga
7) Confidence 0.63 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
We noticed that Bmp7 expression was turned on late during formation of one ruga (just as Shh).
Gene_expression (expression) of Bmp7 in ruga
8) Confidence 0.63 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
No changes in the mRNA expression levels of Bmp7, a protein involved in the activation of the program of brown adipogenesis, was observed.
Gene_expression (expression) of Bmp7
9) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.87 Pain Relevance 0
Nevertheless, protein expression levels of Bmp7 were increased in mice lacking the iNOS gene.
Gene_expression (expression) of Bmp7
10) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 0.77 Pain Relevance 0
BMP7 expression is unaffected by absence of Eya1 [11].
Gene_expression (expression) of BMP7
11) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0
The pharyngeal pouch endoderm expresses BMP7, which has been shown to induce the formation of epibranchial placodes when ectopically expressed in a chick embryo.
Gene_expression (expresses) of BMP7 in epibranchial placodes
12) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0 Pain Relevance 0
E. vivo gene transfer of BMP-7 may be an effective method for inducing dentin regeneration in teeth with reversible pulpitis.
Gene_expression (transfer) of BMP-7 in teeth associated with pulpitis
13) Confidence 0.50 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11767280 Disease Relevance 0.27 Pain Relevance 0.17
BMP-7 gene transfer to inflamed ferret dental pulps.
Gene_expression (transfer) of BMP-7 in dental pulps
14) Confidence 0.50 Published 2001 Journal Eur. J. Oral Sci. Section Title Doc Link 11767280 Disease Relevance 0.16 Pain Relevance 0.15
Exogenous BMP-7 upregulated expression of Id2 and Id3 in injured lenses, and gene introduction of Id2 or Id3 also upregulated BMP-7 expression.
Gene_expression (expression) of BMP-7 in lenses
15) Confidence 0.37 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of the lens epithelial cells as evaluated by histology and expression patterns of alpha-smooth muscle actin and collagens in association with reduction of Smad2 COOH-terminal phosphorylation.
Gene_expression (transfer) of BMP-7 in lens associated with injury
16) Confidence 0.37 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
We have examined the effect of adenovirus-mediated expression of bone morphogenic protein-7 (BMP-7) and inhibitors of differentiation 2 and 3 (Id2 and Id3) on injury-induced epithelial-to-mesenchymal transition (EMT) of lens epithelium in mice.
Spec (examined) Gene_expression (expression) of bone morphogenic protein-7 in lens epithelium associated with injury
17) Confidence 0.37 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.24 Pain Relevance 0.06
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of lens epithelial cells and subsequent sealing of the capsular break with fibrous tissue in mice.
Gene_expression (transfer) of BMP-7 in lens associated with injury
18) Confidence 0.37 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.33 Pain Relevance 0.07
We have examined the effect of adenovirus-mediated expression of bone morphogenic protein-7 (BMP-7) and inhibitors of differentiation 2 and 3 (Id2 and Id3) on injury-induced epithelial-to-mesenchymal transition (EMT) of lens epithelium in mice.
Spec (examined) Gene_expression (expression) of BMP-7 in lens epithelium associated with injury
19) Confidence 0.37 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.24 Pain Relevance 0.06
superfamily molecules, especially BMP4, BMP7, and TGF?
Gene_expression (molecules) of BMP7
20) Confidence 0.29 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.94 Pain Relevance 0.32

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