INT10031

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Context Info
Confidence 0.31
First Reported 1992
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.67
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
Anatomy Link Frequency
saphenous veins 1
platelet 1
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 78.56 Quite High
Pain 3 77.36 Quite High
fibrosis 2 27.72 Quite Low
headache 1 25.00 Low Low
bradykinin 22 19.96 Low Low
antagonist 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 29 86.64 High High
Diabetes Mellitus 5 82.08 Quite High
Cv Unclassified Under Development 2 78.56 Quite High
Pain 3 77.36 Quite High
Pre-eclampsia 66 76.64 Quite High
Fibromyalgia 2 67.64 Quite High
Hypertension 10 41.44 Quite Low
Fibrosis 2 27.72 Quite Low
Thrombosis 2 14.72 Low Low
Syndrome 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate prostacyclin and thromboxane release, segments from the human saphenous veins were investigated in 53 patients.
Spec (investigate) Positive_regulation (investigate) of prostacyclin in saphenous veins
1) Confidence 0.31 Published 1992 Journal World J Surg Section Abstract Doc Link 1455886 Disease Relevance 0.53 Pain Relevance 0.12
Experimental evidence indicates that inhibition of platelet aggregation induced by D-003 is associated with a reduction of thromboxane B2 (TxB2) and an increase of prostacyclin (Pgl2) serum levels.
Positive_regulation (increase) of prostacyclin in platelet
2) Confidence 0.09 Published 2004 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 15689052 Disease Relevance 0 Pain Relevance 0
The temporal patterns of increase in the circulating and urinary levels of five vasodilator factors/systems, prostacyclin, nitric oxide, kallikrein, angiotensin-(1–7) and VEGF, in normal pregnant women and animals, as well as the changes observed in preeclamptic pregnancies support their functional role in maintaining normotension by opposing the vasoconstrictor systems.
Positive_regulation (increase) of prostacyclin
3) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2739214 Disease Relevance 0 Pain Relevance 0
For more than 20 years there has been evidence that in normal pregnancy urinary metabolites of prostacyclin increase progressively, attaining up to 5-fold rise during the last month of pregnancy.
Positive_regulation (increase) of prostacyclin
4) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.14 Pain Relevance 0

General Comments

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