INT100322

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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.56
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (AQP2) plasma membrane (AQP2) protein complex (AQP2)
transmembrane transport (AQP2) lysosome (AQP2) cytoplasm (AQP2)
Anatomy Link Frequency
plasma 2
duct 2
urine 1
AQP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 98.64 Very High Very High Very High
Central nervous system 2 16.48 Low Low
antagonist 40 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.44 Very High Very High Very High
Hyponatremia 128 72.40 Quite High
Volume Depletion And Dehydration 6 70.32 Quite High
Syndrome 8 40.48 Quite Low
Pressure And Volume Under Development 14 27.28 Quite Low
Cancer 2 18.40 Low Low
Heart Rate Under Development 28 5.00 Very Low Very Low Very Low
Myocardial Infarction 28 5.00 Very Low Very Low Very Low
Cirrhosis 16 5.00 Very Low Very Low Very Low
Diuresis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of an acute oral ibuprofen intake on urinary aquaporin-2 excretion in healthy humans.
Localization (excretion) of aquaporin-2
1) Confidence 0.80 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Title Doc Link 11768323 Disease Relevance 0.10 Pain Relevance 0.20
We suggest that the increased excretion of AQP2 can be explained by an increase in the ratio of AQP2 that is shed into the urine because the endocytic retrieval of AQP2 from the apical membrane is impaired.
Localization (excretion) of AQP2 in urine
2) Confidence 0.80 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11768323 Disease Relevance 0 Pain Relevance 0
When release is stimulated, the circulating AVP binds to AVP V2 receptors on the principal cells of the collecting duct of the kidney, activating a cyclic AMP-mediated signal transduction pathway that stimulates insertion of aquaporin-2 (AQP2) water channels into the apical membrane of the principal cells.1 The AQP2 channels lead to increased permeability of the renal collecting duct and reabsorption of water along osmotic gradients, thereby producing an antidiuresis.
Localization (insertion) of AQP2 in duct
3) Confidence 0.73 Published 2010 Journal Core evidence Section Body Doc Link PMC2899773 Disease Relevance 0.14 Pain Relevance 0
The purpose was to measure the effect of ibuprofen on urinary excretion of aquaporin-2 (u-AQP2), urinary output, urinary osmolality (u-osm) and plasma concentration of vasopressin (AVP) in a dose-response study using placebo and ibuprofen 600mg and 1200mg.
Localization (excretion) of aquaporin-2 in plasma
4) Confidence 0.70 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11768323 Disease Relevance 0.09 Pain Relevance 0.18
The purpose was to measure the effect of ibuprofen on urinary excretion of aquaporin-2 (u-AQP2), urinary output, urinary osmolality (u-osm) and plasma concentration of vasopressin (AVP) in a dose-response study using placebo and ibuprofen 600mg and 1200mg.
Localization (excretion) of AQP2 in plasma
5) Confidence 0.70 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11768323 Disease Relevance 0.09 Pain Relevance 0.18
When release is stimulated, the circulating AVP binds to AVP V2 receptors on the principal cells of the collecting duct of the kidney, activating a cyclic AMP-mediated signal transduction pathway that stimulates insertion of aquaporin-2 (AQP2) water channels into the apical membrane of the principal cells.1 The AQP2 channels lead to increased permeability of the renal collecting duct and reabsorption of water along osmotic gradients, thereby producing an antidiuresis.
Localization (insertion) of aquaporin-2 in duct
6) Confidence 0.27 Published 2010 Journal Core evidence Section Body Doc Link PMC2899773 Disease Relevance 0.14 Pain Relevance 0

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