INT100328

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.41
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (AQP2) plasma membrane (AQP2) protein complex (AQP2)
transmembrane transport (AQP2) lysosome (AQP2) cytoplasm (AQP2)
Anatomy Link Frequency
plasma 2
kidney collecting duct 2
nervous system 1
duct 1
AQP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 2 96.08 Very High Very High Very High
adenocard 2 95.68 Very High Very High Very High
Central nervous system 21 92.84 High High
carbamazepine 22 90.48 High High
cINOD 4 89.84 High High
medulla 2 64.72 Quite High
sSRI 6 62.56 Quite High
Trigeminal neuralgia 4 59.28 Quite High
neuralgia 1 56.08 Quite High
Spinal cord 18 53.60 Quite High
Disease Link Frequency Relevance Heat
Diabetes Insipidus 7 97.80 Very High Very High Very High
Hyponatremia 197 96.96 Very High Very High Very High
Targeted Disruption 18 96.36 Very High Very High Very High
INFLAMMATION 8 89.28 High High
Cataract 3 87.12 High High
Increased Venous Pressure Under Development 10 79.88 Quite High
Myocardial Infarction 32 79.04 Quite High
Pressure And Volume Under Development 46 78.44 Quite High
Depression 3 69.72 Quite High
Polyuria 5 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, a 40% increase in the expression of the water channel aquaporin-2 water in the renal collecting duct was shown, suggesting a direct renal effect of the drug.
Gene_expression (expression) of water channel aquaporin-2 in duct
1) Confidence 0.75 Published 2009 Journal NDT Plus Section Body Doc Link PMC2762828 Disease Relevance 0.75 Pain Relevance 0.51
The purpose was to measure the effect of ibuprofen on urinary excretion of aquaporin-2 (u-AQP2), urinary output, urinary osmolality (u-osm) and plasma concentration of vasopressin (AVP) in a dose-response study using placebo and ibuprofen 600mg and 1200mg.
Gene_expression (excretion) of aquaporin-2 in plasma
2) Confidence 0.67 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11768323 Disease Relevance 0.09 Pain Relevance 0.18
The purpose was to measure the effect of ibuprofen on urinary excretion of aquaporin-2 (u-AQP2), urinary output, urinary osmolality (u-osm) and plasma concentration of vasopressin (AVP) in a dose-response study using placebo and ibuprofen 600mg and 1200mg.
Gene_expression (excretion) of AQP2 in plasma
3) Confidence 0.67 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11768323 Disease Relevance 0.09 Pain Relevance 0.18
The subgroup of aquaporins is composed of AQP0, AQP1, AQP2, AQP4, AQP5, AQP6 and AQP8 and is considered to be mainly permeable to water with a high flow rate.
Gene_expression (composed) of AQP2
4) Confidence 0.27 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0 Pain Relevance 0
AQP2 is permeable to water and is expressed in kidney collecting duct [95]; its mutations can cause an autosomal form of hereditary nephrogenic diabetes insipidus in humans [21].
Gene_expression (expressed) of AQP2 in kidney collecting duct associated with diabetes insipidus
5) Confidence 0.24 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.40 Pain Relevance 0.09
In addition, recent data reported the expression of AQP2 isoform also in the nervous system [15, 17].
Gene_expression (expression) of AQP2 in nervous system
6) Confidence 0.24 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.45 Pain Relevance 0.11
In the presence of AVP and an intact hypertonic medullary interstitium, AVP, mediated by V2 receptors, upregulates the expression and trafficking of aquaporin-2 to the luminal side of the collecting tubules and allows water to be reabsorbed efficiently into a more tonic medullary milieu.
Gene_expression (expression) of aquaporin-2 in collecting tubules
7) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.17 Pain Relevance 0
The down-stream effect is enhanced production and trafficking of the water channels aquaporin-2 to the luminal membranes to facilitate water reabsorption into the hypertonic medullary interstitium.
Gene_expression (production) of aquaporin-2
8) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504060 Disease Relevance 0.45 Pain Relevance 0.13

General Comments

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