INT100344

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.60
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
sensory neurons 2
nerve 2
neurons 2
pineal gland 2
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 26 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
Antinociceptive 2 99.80 Very High Very High Very High
Neuropathic pain 22 98.84 Very High Very High Very High
lidocaine 7 98.68 Very High Very High Very High
Pain 70 96.52 Very High Very High Very High
Peripheral nerve injury 1 95.80 Very High Very High Very High
Eae 26 93.44 High High
Adelta 1 91.60 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 29 100.00 Very High Very High Very High
Neuropathic Pain 64 98.84 Very High Very High Very High
Pain 73 96.52 Very High Very High Very High
Nervous System Injury 21 95.80 Very High Very High Very High
Sprains And Strains 128 86.40 High High
Targeted Disruption 4 81.16 Quite High
Nociception 3 40.64 Quite Low
Injury 3 17.20 Low Low
Neuroma 6 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This facility is illustrated by outlier values for Gal and Scn11a expression in two ostensibly nerve injured mice, both C58.
Regulation (values) of Gene_expression (expression) of Scn11a in nerve
1) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.49 Pain Relevance 0.17
In conclusion, our data demonstrate that the expression of Na(v)1.8 in sensory neurons can confine the antinociceptive efficacy of lidocaine and other Na+ channel blockers employed for pain treatment.
Regulation (confine) of Gene_expression (expression) of Na in sensory neurons associated with pain, lidocaine and antinociceptive
2) Confidence 0.30 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20174994 Disease Relevance 0.60 Pain Relevance 1.41
In this review we focus on Na+ channels that are selectively expressed in DRG neurons as potential analgesic drug targets.
Regulation (targets) of Gene_expression (expressed) of Na in neurons associated with dorsal root ganglion and analgesic
3) Confidence 0.10 Published 2002 Journal Novartis Found. Symp. Section Abstract Doc Link 11771644 Disease Relevance 0.51 Pain Relevance 0.62
In the present study, the stimulatory effect of morphine on the expression of NAT mRNA in the rat pineal gland has been demonstrated using semi-quantitative RT-PCR technique.
Regulation (effect) of Gene_expression (expression) of NAT mRNA in pineal gland associated with morphine
4) Confidence 0.01 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16095816 Disease Relevance 0 Pain Relevance 0.63

General Comments

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