INT100350

Context Info Confidence 0.44 First Reported 2001 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.46 Pain Relevance 0

extracellular space (IFNA2) extracellular region (IFNA2) cell-cell signaling (IFNA2)

Anatomy Link Frequency shields 2 IFNA2 (Homo sapiens)

Pain Link Frequency Relevance Heat headache 2 25.00

Disease Link Frequency Relevance Heat Chronic Hepatitis 12 83.76 Cirrhosis 12 69.60 Hepatitis C Virus Infection 6 31.60 Myalgia 2 25.00 Fatigue 2 25.00 Headache 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Peginterferon-alpha-2a (40 kD) is produced by the covalent attachment of recombinant interferon-alpha-2a to a branched mobile 40 kD polyethylene glycol moiety, which shields the interferon-alpha-2a molecule from enzymatic degradation, reduces systemic clearance and enables once-weekly administration.

Protein_catabolism (degradation) of interferon-alpha-2a in shields

1) Confidence 0.44 Published 2001 Journal Drugs Section Abstract Doc Link 11772139 Disease Relevance 0.23 Pain Relevance 0

Peginterferon-alpha-2a (40KD) is produced by the covalent attachment of recombinant interferon-alpha-2a to a branched mobile 40KD polyethylene glycol moiety, which shields the interferon-alpha-2a molecule from enzymatic degradation, reduces systemic clearance and enables once-weekly administration.

Protein_catabolism (degradation) of interferon-alpha-2a in shields

2) Confidence 0.44 Published 2002 Journal BioDrugs Section Abstract Doc Link 12102649 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.