INT100360

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 10.43
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
blood 1
medulla 1
colon 1
brain 1
umbilical vein 1
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
tail-flick 6 100.00 Very High Very High Very High
agonist 6 99.48 Very High Very High Very High
medulla 6 99.10 Very High Very High Very High
Glutamate 2 96.92 Very High Very High Very High
Inflammation 61 95.60 Very High Very High Very High
addiction 16 95.48 Very High Very High Very High
Angina 22 89.44 High High
rheumatoid arthritis 104 88.44 High High
cytokine 40 82.88 Quite High
Glutamate receptor 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Apoptosis 81 99.62 Very High Very High Very High
Thrombosis 31 99.36 Very High Very High Very High
Stress 33 99.00 Very High Very High Very High
Anaemia 74 98.94 Very High Very High Very High
Chronic Disease 8 98.08 Very High Very High Very High
Endotoxemia 2 97.76 Very High Very High Very High
Increased Venous Pressure Under Development 3 97.56 Very High Very High Very High
Disease 81 97.52 Very High Very High Very High
Colon Cancer 19 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with rhGH has been shown to reduce protein catabolism,13,14 increase muscle area and strength,14–18 increase erythropoietin synthesis,19 and to improve inflammation status and quality of life.20 A recent 6-month study showed a positive effect of GH treatment on lean body mass and cardiovascular risk factors.21 Furthermore, GH administration is associated with improvements in several nutritional parameters, such as increases in serum insulin-like growth factor-I (IGF-I),13,14,22 serum albumin14 and transferrin,13 and a reduction in blood urea nitrogen.13
Negative_regulation (reduction) of transferrin in blood associated with inflammation
1) Confidence 0.42 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.56 Pain Relevance 0.05
According to a receiver operating characteristic (ROC) analysis patients were categorized into 2 groups: the high-TF activity group included patients with TF values >24 pmol/L, the low TF activity group included patients with TF values ?
Negative_regulation (group) of TF
2) Confidence 0.42 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.90 Pain Relevance 0
CONCLUSIONS: Histamine induces expression of TF, but not TF pathway inhibitor, in vascular cells via activation of the H1, but not H2, receptor.
Negative_regulation (inhibitor) of TF
3) Confidence 0.38 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
The Youden-index was used to determine statistically reliable cut-off value of TF by maximizing the sum of sensitivity and specificity in reference to observed survival state.
Negative_regulation (value) of TF
4) Confidence 0.37 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.17 Pain Relevance 0
To inhibit endogenous TFPI TF activity was measured using an FXa generation assay in the absence and presence of 100 ?
Negative_regulation (inhibit) of TF
5) Confidence 0.37 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.57 Pain Relevance 0.22
Here we demonstrate that BCX-3607, a small molecule potent inhibitor of TF/FVIIa, reduces thrombus weight in an animal model of DVT.
Negative_regulation (inhibitor) of TF associated with thrombosis
6) Confidence 0.36 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16378835 Disease Relevance 1.24 Pain Relevance 0.24
Additionally, in vitro studies indicate that BCX-3607 blocks the generation of TF/FVIIa-induced IL-8 mRNA in human keratinocytes and reduces the TF/FVIIa-mediated generation of IL-6 and IL-8 in human umbilical vein endothelial cells (HUVEC).
Negative_regulation (blocks) of TF in umbilical vein
7) Confidence 0.36 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16378835 Disease Relevance 1.15 Pain Relevance 0.23
In this study an apoptosis associated with a decrease of transferrin receptors and oxidative stress were induced by geoditin A in colon cancer HT29 cells, and this apoptosis was diminished by pre-treatment with oxidant scavenger, N-acetylcysteine, implicating the apoptosis inducing activity of geoditin A is mediated through oxidative stress.

2.

Negative_regulation (decrease) of transferrin in colon associated with stress, colon cancer and apoptosis
8) Confidence 0.20 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.90 Pain Relevance 0
Tfn endocytosed into HT29 cells and accumulated in the early/late and recycling endosomes in the cytoplasm (Figure 5a), but the level of endocytic Tfn-fluorescence decreased in a dose-dependent manner in geoditin A-treated cells (Figures 5b–d), and a decrease of >30% labeled transferrin in these cells was measured by flow cytometric analysis (Figure 5e).
Negative_regulation (decrease) of transferrin
9) Confidence 0.20 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.35 Pain Relevance 0
HT29 cells were pre-treated with serial concentrations of geoditin A for 24 h, depleted endogenous transferrin by incubating in plain DMEM containing 1% BSA for 1 h before transferrin uptake assay was performed for 1 h in DMEM containing 50 ?
Negative_regulation (depleted) of transferrin
10) Confidence 0.20 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0 Pain Relevance 0
Chemical activation of metabotropic glutamate (mGlu) receptors by local injection of (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (tACPD), the mGlu receptor agonist, produced a dose-related inhibition of the TF reflex.
Negative_regulation (inhibition) of TF associated with glutamate, tail-flick and agonist
11) Confidence 0.16 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12117598 Disease Relevance 0.16 Pain Relevance 0.63
1, characterized by blunted and delayed down-regulation of PRL, IGFBP-1, and TF transcripts, which was not associated with a significant reduction in secretion of PRL or IGFBP-1 proteins.
Negative_regulation (down-regulation) of TF
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
Second, when IL-6 is infused to healthy individuals, the hepcidin level increases, and serum iron and transferrin saturation decrease (7).
Negative_regulation (decrease) of transferrin
13) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826733 Disease Relevance 2.01 Pain Relevance 0.47
Anemia of chronic disease was defined as normo- to microcytic anemia with decreased serum iron concentrations, normal to decreased transferrin levels and normal or increased serum ferritin levels (10).
Negative_regulation (decreased) of transferrin associated with anaemia and chronic disease
14) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826733 Disease Relevance 1.16 Pain Relevance 0.20
In this study, we provide evidence that focal electrical stimulation applied to the rostroventral medulla (RVM) at a high frequency (100 Hz) produced inhibition of the spinal nociceptive tail-flick (TF) reflex in lightly anesthetized adult rats.
Negative_regulation (inhibition) of TF in medulla associated with nociception, medulla and tail-flick
15) Confidence 0.11 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12117598 Disease Relevance 0.17 Pain Relevance 0.45
as a classifier to detect TF targets.
Negative_regulation (detect) of TF
16) Confidence 0.03 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC3017040 Disease Relevance 0 Pain Relevance 0.05
0 as defined in equation 7 of phase locked TF and target pairs.
Negative_regulation (locked) of TF
17) Confidence 0.02 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC3017040 Disease Relevance 0 Pain Relevance 0
More examples of high order locked pairs from the cell cycle genes, and TF-target pairs are given in Additional files 4 &5.
Negative_regulation (locked) of TF
18) Confidence 0.02 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC3017040 Disease Relevance 0 Pain Relevance 0.04
Both insulin and transferrin receptors are enriched in cerebral ECs, but relatively tiny amounts of insulin and transferrin are delivered into the brain mass via RMT.
Negative_regulation (amounts) of transferrin in brain
19) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.06 Pain Relevance 0
Tissue factor pathway inhibitor (TFPI), the only endogenous inhibitor of the TF/Factor VIIa (FVIIa) complex, has recently been characterised biochemically and pharmacologically.
Negative_regulation (inhibitor) of TF
20) Confidence 0.01 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772296 Disease Relevance 0.64 Pain Relevance 0.10

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