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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) transcription factor binding (Vhl) cytoplasm (Vhl)
Anatomy Link Frequency
endothelial cells 2
Vhl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 8 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 7 99.08 Very High Very High Very High
Cancer 3 75.00 Quite High
Ulcers 1 56.80 Quite High
INFLAMMATION 1 53.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that NSAIDs inhibit hypoxia-induced angiogenesis in endothelial cells by inhibiting VEGF and Flt-1 expression through increased VHL expression and the resulting ubiquitination and degradation of HIF-1alpha.
Negative_regulation (inhibiting) of Gene_expression (expression) of VHL in endothelial cells associated with hypoxia and cinod
1) Confidence 0.06 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.90 Pain Relevance 0.62

General Comments

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